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which affects a large population of the elderly. In the past few decades, our understanding of the molecular and cellular mechanisms underlying the changes associated with aging and age-related diseases has expanded greatly, shedding light on the potential role of these changes in cognitive impairment...
Hypertension and Age-Related Changes in the HeartImplications for Drug Therapy Heart disease in older individuals can be characterised as the result of 2 processes, hypertension and atherosclerosis, which are the major causes of heart... S Isoyama - 《Drugs & Aging》 被引量: 0发表: 1994年 加...
Drosophila melanogaster , powerfully models the genetics of aging. Rodents are also well suited to model human age-related hearing loss. Nonhuman primates are excellent proxies for humans as they possess similar brain structure and age-related degradation of the dopaminergic system....
Cellular senescence is the hallmark of aging41,42. Cellular senescence in the brain may link the aging process to AD progression. The senescence of astrocytes is related to AD pathogenesis43. In a study on the senescence of astrocytes in AD patients, senescent astrocytes showed upregulated ...
Apolipoprotein E (ApoE) is the predominant carrier for cholesterol transport from astrocytes to neurons in the brain (Zhang & Liu, 2015). There are three major alleles of the ApoE gene in humans, coding for ApoE2, ApoE3, and ApoE4, respectively. ApoE4 is a major risk factor for AD (Zh...
Human gait recognition, an active research topic in computer vision, is generally based on data obtained from images/videos. We applied computer vision technology to classify pathology-related changes in gait in young children using a foot-pressure database collected using the GAITRite walkway system...
关键词: Humans Jaw Diseases Temporomandibular Joint Dysfunction Syndrome Mouth Diseases Tooth Diseases Psychophysiologic Disorders Depression Hypochondriasis Aging Aged 被引量: 1 年份: 1990 收藏 引用 批量引用 报错 分享 全部来源 求助全文 NCBI NCBI Europe PMC ResearchGate mysciencework.com 查看更多 相似文献...
作者: DLD Caspar 摘要: National Academy of Sciences 关键词: Animals Humans Saccharomyces cerevisiae Alzheimer Disease Amyloid Crystallography, X-Ray Static Electricity Amyloid beta-Peptides Prions Hydrogen Bonding DOI: 10.1073/pnas.0910978107 被引量: 13 年份: 2009 收藏...
In mouse models, TMEM106B deficiency leads to lysosome trafficking and myelination defects and FTLD related pathology. In humans, alterations in TMEM106B levels or function are intimately linked to neuronal proportions, brain aging, and brain disorders. Further elucidation of the physiological function...