LasI合成3-oxoC12-HSL,可激活细胞质受体。LasR调节溶血素、蛋白酶、弹性蛋白酶和外毒素-a产生基因的表达,用于生物膜形成。铜绿假单胞菌中的LasR被鉴定为lasB基因表达的关键调控因子,该基因编码一种金属蛋白酶弹性蛋白酶。随后,LasR被证明对aprA、lasA和toxA的转录是必需的。因此,它被认为是铜绿假单胞菌毒力基因的...
Moore,NM,Flaws ML.Epidemiology and pathogenesis of Pseudomonas aeruginosa infections. Clinical Laboratory Science . 2011Epidemiology and Pathogenesis of Pseudomonas aeruginosa Infections[J] . Moore, Nicholas M,Flaws, Maribeth L.Clinical Laboratory Science . 2011 (1)...
The gram-negative opportunistic bacterial pathogen, Pseudomonas aeruginosa, is an important etiologic agent of a variety of infectious diseases affecting the eye and surrounding tissues. The number of clinical studies and studies with mouse, guinea pig, and rabbit models of Pseudomonas-induced ocular di...
The incidence of production and biological activity of various extracellular factors of Pseudomonas aeruginosa from leukaemic and non-leukaemic patients were investigated. A panel of 157 isolates was constructed from blood of leukaemic (Group I), and other body sites of the same patients (Group II)...
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive pulmonary disorder (COPD), cancer, and severe infection requiring ventilation,
of Koch to be used as a framework to assess the causation between intestinal Pseudomonas aeruginosa and intestinal disease in patients with cancer. In the following sections we describe the prevalence of P. aeruginosa in cancer and the immunosuppressive and stress-inducing conditions of cancer that ...
(1987). Pathogenesis of acute and chronic Pseudomonas aeruginosa infections. Antibiot Chemother (1971), 39, 160-171.Woods DE (1987) Pathogenesis of acute and chronic Pseudomonas aeruginosa infections. Antibiot Chemother (1971) 39: 160-171.
Pseudomonas aeruginosa, an opportunistic Gram-negative bacterium, is the principal cause of hospital-acquired pneumonia, and is responsible for the high morbidity and mortality in cystic fibrosis (CF) patients. P. aeruginosa also causes a wide range of human diseases including otitis media, keratitis...
P930 Virulence factors ofPseudomonas aeruginosafrom cystic fibrosis patients and the effects of subinhibitory concentrations of erythromycin A. Raftopoulou, A. Chrissaki, V. Marnali, C. Skarmoutsou, A. Limioti, N. Microgiannaki, A. Pangalis.Clinical Microbiology Laboratory, ‘Aghia Sophia‘Chil...
Microbial pathogenesis in cystic fibrosis: co-ordinate regulation of heat-shock response and conversion to mucoidy in Pseudomonas aeruginosa. Conversion of Pseudomonas aeruginosa to the mucoid phenotype plays a major role in the pathogenesis of respiratory infections in cystic fibrosis (CF). One ... ...