(2008). Pathogenesis of the metabolic syndrome. Ann. Dermatol. Venereol. 135, 243-248.JULLIEN D.Pathogenesis of the metabolic syndrome. Annales de Dermatologie et de Venereologie . 2008Jullien D.Pathogenesis of the metabolic syndrome. Annales de Dermatologie et de Venereologie . 2008...
Therefore, this review mainly focuses on the roles of adipose tissue dysfunction in inflammation, insulin resistance, and oxidative stress in the pathogenesis of metabolic syndrome. 展开 关键词: Metabolic syndrome Adipose tissue dysfunction Insulin resistance Inflammation Oxidative stress ...
Lipodystrophy, and the metabolic alterations (dislipemia, insulin-resistance) associated with human immunodeficiency virus (HIV) infection, is a multifactorial syndrome due to the interaction of host related factors (cellular immune status, diet, gene mutations), viral factors (cytokine synthesis, polyun...
Role of mitochondria in pathogenesis of metabolic problems such as obesity, metabolic syndrome, and T2DM is the focus of many recent research studies. Mitochondrial dysfunction contributes to the oxidative stress and systemic inflammation leading to insulin resistance (IR). Mitochondria are also essential...
mTOR-driven inflammation also reflects immuno-metabolic stress in autoimmune type 1 diabetes, inflammatory bowel disease, multiple sclerosis, and Sjogren syndrome. Blockade of mitochondrial oxidative stress, mTOR activation, and activation of AMP-activated protein kinase may offer benefit in most autoimmune...
Elevenbeta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1), a key intracellular enzyme which catalyses the conversion of inactive cortisone to active cortisol, has been implicated in the development of the metabolic syndrome. The shift of this reaction towards cortisol generation may lead to ...
This article reviews the recent literature data and current concepts for ICP, with emphasis on a possibility of metabolic disorders being primary causative factors in ICP pathogenesis. 展开 关键词: intrahepatic cholestasis, pregnancy, bile acid, metabolic syndrome, irisin ...
Metabolic diseases, such as obesity, diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD), are abnormal conditions that result from disturbances of metabolism. With the improvement of living conditions, the morbidity and mortality rates of metabolic diseases are steadily rising, posing a ...
whilst that of NASH was redefined as metabolic dysfunction-associated steatohepatitis (MASH) [12]. Given the correlation between MASLD and metabolic syndrome, it often coexists with metabolic disorders [13]. At the same time, MASLD involves multiple pathogenic molecular pathways, thus leading to hete...
The role of nuclear receptors in the kidney in obesity and metabolic syndrome control a large variety of metabolic processes, including kidney lipid metabolism, drug clearance, inflammation, fibrosis, cell differentiation, and oxidative ... C Tovar-Palacio,N Torres,A Diaz-Villase?Or,... - 《Gen...