We must aim for a better understanding of the genetic determinants of this manifestation (to help identify those who are at risk) as well as its pathogenesis (to help identify therapeutic targets). This review aims to provide a summary of the key genetic determinants of CTD-IL...
P Venerino - 《European Respiratory Review An Official Journal of the European Respiratory Society》 被引量: 1发表: 2014年 How Do We Identify and Manage Progressive CTD-ILD?-Update in Treatment and Guideline By targeting the underlying mechanism of pulmonary fibrosis, it is shown that the annua...
Connective tissue diseases (CTD) might be associated with various malignancies, and one of the most frequent is lung cancer (LC). Despite our understanding... Tatjana N. Adi a,Dragica P. Peut a,Ljudmila M. Nagorni-Obradovi a,... - 《Respiratory Medicine》 被引量: 44发表: 2008年 ...
PATHOGENESISInterstitial lung disease (ILD) is one of the most serious lung complications of connective tissue disease (CTD). The application of proteomics in the past decade has revealed that various proteins are involved in the pathogenesis of each subtype of CTD-ILD through...
gren's syndrome, systemic lupus erythematosus (SLE), undifferentiated CTD, and mixed CTD, where ILD is a less frequent complication (Table 1). In addition to ILD, other forms of lung damage involving the pleura, vasculature, airways, and lymphatic tissues can complicate CTDs. These ...
Deterioration of TRPG was seen in one patient after receiving pulmonary vasodilators. One with severe ILD developed PH. Conclusions The pathogenesis of borderline mean PAP, clearly distinctive from normal mean PAP, was heterogeneous as that of manifest PH in CTD patients. Though the clinical course...
We assessed whether the circulating levels of Gas6, sAxl, and sMer marked the presence of cardiopulmonary involvement. Interestingly, we reported that the sMer plasma concentration was significantly higher in the 14 patients with PAH associated with connective tissue disorders (CTD-PAH) compared to ...
as Gene–Disease Associations (GAD) and Gene–Disease Associations (CTD) for MS and OCD, respectively. These genes were also uploaded into two separated tab pages of an Excel file. In the next step, overlap genes between the literature review and Harmonizome database were removed. Finally, com...