Holgate ST: Pathogenesis of asthma. Clin Exp Allergy 2008, 38 (6) : 872–897.STEPHEN T., HOLGATE. (2008) Pathogenesis of Asthma. Clinical & Experimental Allergy 38 , 872-897 /Holgate ST. Pathogenesis of asthma. Clin Exp Allergy. 2008;38:872–97....
Detailed physiological mechanisms of the changing sex ratios with age are not fully known, however, the gender (socio-cultural) factors are also imperative. Although multiple factors definitely influence the pathogenesis of asthma, only individual or few combinations of these have been investigated. ...
Haapakoski R., Karisola P., Fyhrquist N., et al. Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-gamma-dependent mechanisms J Invest Dermatol, 133 (4) (2013), pp. 964-972 ...
Following the example of most fields of respiratory medicine, such as asthma, chronic obstructive pulmonary disease, pulmonary hypertension and lung cancer, combination therapy that includes the use of different molecules in a synergic has a strong rationale [101]. Indeed, the association of drugs wi...
ARTICLES Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis X Qi1, P Gurung1, RKS Malireddi1, PWF Karmaus1, D Sharma1, P Vogel2, H Chi1, DR Green1 and T-D Kanneganti1 Allergic asthma is a chronic inflammatory disorder of the ...
Allergy, Asthma Clin Immunol. 2018;14(Suppl 2):49. https://doi.org/10.1186/s13223- 018-0278-1. 66. Hoffmann J, Akira S. Innate immunity. Curr Opin Immunol. 2013;25(1):1–3. https://doi.org/10.1016/j.coi.2013.01.008. 67. Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun...
Cell Communication and Signaling (2023) 21:314 Page 9 of 26 in asthma and COPD after an oxidative stress challenge has raised more attention to developing effective p38 inhibitors [62]. Another crucial finding is that in model mice, the pre- mature senescence of airway epithelial cells (Clara...
The inhibition of IL-33 has not been demonstrated to be able to impact the course of AD to date, while it has demonstrated some efficacy for the treatment of asthma, a common AD comorbidity [134]. The JAK-STAT signaling pathway and SYK Janus kinases (JAKs) and signal transducer and ...
GPERmay be a potential therapeutic target for the treatment of asthma. Abstract Background and Aim G protein-coupled estrogen receptor (GPER) is an estrogen receptor located on the plasma membrane. We previously reported that the administration of G-1, a GPER-specificagonist, suppressed development...
Circulating fibrocytes have also been considered as a source of CAFs, as they have been shown to be recruited to injured tissues [59], [60] and to contribute to the αSMA myofibroblasts observed in a mouse model of allergic asthma [61]. Furthermore, in a model of bleomycin-induced lung ...