The Pathogen鈥揌ost Interactions Database (PHI-base) has, since 2005, provided manually curated genes from fungal, bacterial and protist pathogens that have been experimentally verified to have important pathogenicity, virulence and/or effector functions during different types of interactions involving ...
48, Database issue D613–D620doi: 10.1093/nar/gkz904PHI-base: the pathogen–host interactions databaseMartin Urban 1 , Alayne Cuzick 1 , James Seager 1 , Valerie Wood 2 , Kim Rutherford 2 , ShilpaYagwakote Venkatesh 3 , Nishadi De Silva 4 , Manuel Carbajo Martinez 4 , Helder Pedro4...
PHI-base – the multi-species pathogen–host interaction database in 2025 The Pathogen鈥揌ost Interactions Database (PHI-base) has, since 2005, provided manually curated genes from fungal, bacterial and protist pathogens that hav... U Martin,C Alayne,S James,... - 《Nucleic Acids Research》...
interactions: To predict new interactions, each PPI from the query dataset was inspected the following way: the host protein in the query PPI was searched against all the pairwise comparisons in the positive database of similar proteins and whenever a match was found, the query interaction was ...
We next searched the pathogen-host interaction database [48] forP. digitatumproteins homologous to effector proteins from other pathogenic fungi [38]. These include not only CRPs but also other types of proteins that can modulate host physiology. Again,P. digitatumencodes a smaller number of homol...
Among the predicted secretome proteins, some may have an important role in pathogenesis. In total, 121 secretome protein genes in CD-56 were assigned in the Pathogen–Host Interaction (PHI) database. The predicted pathogenicity-associated genes from CD-56 were classified into six phenotype-associat...
The host–pathogen interaction during HIV infection is peculiarly complex due to the fact that the virus infects immune cells, and that antiviral immune responses end up paradoxically favoring virus replication through the creation of cellular targets for infection. Several aspects of this complex inter...
The host–pathogen interaction represents a complex and dynamic biological system. The outcome of this interaction is dependent on the microbial pathogen properties to establish infection and the ability of the host to control infection. Although bacterial pathogens have evolved a variety of strategies ...
The skin and contiguous mucosal surfaces define the primary locus of interaction between host and micro-organisms. In this review, we focus on the innate immune system in the mucosa, which manages to deal with invading pathogens, the mechanisms that organisms have evolved in order to circumvent ...
responses and inflammation; to interact with toll-like receptors (TLR2, TLR4 and TLR7)97,98,99to crumple the host immune system, which are the key players of adaptive and innate immunity. In our data, several other proteins are also involved in interaction with pathogen and have a role in...