ORAI3 is involved in the proliferation of lung cancer cells. In breast cancer, it has been reported that ORAI3 is an estrogen receptor α (ERα) and that EGF-regulates its activity. Moreover, both ERα and EGFR play a significant role in the growth of lung carcinomas.Design: ...
Neuroendocrine lung cancer is among the most common types of lung cancers in smokers. We have recently shown that exposure of hamsters to N-nitrosodiethylamine and hyperoxia causes a high incidence of this tumor type. In this study, we show that the tobacco-specific nitrosamine 4-(methylnitros...
C L E I N F O Keywords: CircRNA Lung cancer Biomarker A B S T R A C T Lung cancer is among the leading causes of cancer mortality and incidence in both sexes. Different classes of transcripts have been proposed as molecular markers in this type of cancer. Circular RNAs (circRNAs) are...
Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a variety of factors, including liver injury, inflammatory cells, inflamm
(TME)—which may influence tumour cells to proliferate and invade or to starve and die. In that regard, stromal cells—including fibroblasts, smooth muscle cells and vasculature-associated cells—constitute an essential fraction of the prostate cancer TME. However, they have been largely overlooked ...
期刊名称:《Pathobiology: journal of immunopathology, molecular and cellular biology》 | 2010年第6期 4.Gene promoter methylation and its potential relevance in early prostate cancer diagnosis. 机译:基因启动子甲基化及其在早期前列腺癌诊断中的潜在相关性。 作者:Steiner I;Jung K;Schatz P;Horns T;Witt...
Because of these changes, the fields of liver vasculature and portal hypertension have recently become closely integrated within the broader vascular biology discipline. As developments in vascular biology have evolved, a deeper understanding of vascular processes has led to a better understanding of the...
HER2 protein overexpression in breast cancer [34] and GC [35], and anaplastic lymphoma kinase (ALK) protein expression in lung cancer [36] are examples of therapeutically significant proteins that can be assessed by IHC. However, it was unknown whether previously reported FGFR2 IHC data ...
A. The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease. Nat. Rev. Nephrol. 11, 515–534 (2015). CAS PubMed PubMed Central Google Scholar Luengo, A., Gui, D. Y. & Vander Heiden, M. G. Targeting metabolism for cancer therapy. Cell Chem. Biol. 24, ...
Because the lymphoma type, cellular morphology, and organ distribution reported in these studies are atypical of lymphoma in rats, because lymphocyte and plasma cell accumulation in the lung is characteristic of M. pulmonis disease, and because M. pulmonis disease can be exacerbated by experimental ...