It will also be important to determine whether these pathogenic proteins participate in the molecular events leading to neurodegeneration in existing animal models of PD, in order to evaluate how closely these models mimic the pathogenic events of the human disease. Here, after discussing clinical ...
This chapter introduces the basic pathological hallmarks and general risk factors associated with Parkinson's Disease (PD). It then briefly introduces genetic and environmental factors linked to PD. The classic and emerging animal models used to study PD pathogenesis are included to discuss their ...
Parkinson’s disease: mechanisms and models. Neuron 39, 889–909 (2003). CAS PubMed Google Scholar Rodriguez-Oroz, M. C. et al. Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms. The Lancet Neurology 8, 1128–1139 (2009). CAS PubMed Google ...
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The abnormal accumulation of α-synuclein (α-syn) is a crucial factor for the onset and pathogenesis of Parkinson’s disease (PD), and the autophagy-lysosome pathway (ALP) contributes to α-syn turnover. AMP-activated protein kinase (AMPK) and the mamma
Parkinson’s DiseaseExperimental modelsReserpine6-HydroxydopamineRotenoneDrosophiliaZebrafish1-Methyl-4-Phenyl-1236-Tetrahydropyridine (MPTP)HaloperidolAbout 1.5% of the world's population is suffering from Parkinson's disease, mostly above 55 years of age. It is identified by dopaminergic neuron loss in ...
Some animal models exclusively reflect the symptoms of the disease or just a small fraction of them [9]. Further, not all findings of the animal models can be easily transferred to human beings, and it is not possible to investigate the molecular mechanisms of PD in a living human being. ...
Barcia, C., Ros, C. M., Annese, V., et al., “IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease,”Cell Death Dis.,2, No. 4, e142 (2011). ...
Parkinson's disease(PD) is a progressive neurodegenerative disorder,and the pathogenesis of PD is not completely understood.Establishing in vitro cell models is an important way to research the pathophysiologic mechanisms and explore new drug targets for PD treatment.关键词: Parkinson's disease cell ...
Novel molecular and cellular treatments provide new tools to prevent and alleviate Parkinson's disease.doi:10.1016/S0361-9230(01)00773-0Ole IsacsonElsevier Inc.Brain Research BulletinIsacson O. (2002) Models of repair mechanisms for future treatment modalities of Parkinson's disease. Brain Res. ...