Dementia associated with Parkinson's disease (PDD) is a common problem and one that is associated with significant morbidity and mortality. Over the past decade, increasing research efforts and funding have been directed toward an improved understanding of PDD. Despite these efforts, fundamental gaps...
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, most commonly characterised by motor dysfunction, but also with a high prevalence of cognitive decline in the decades following diagnosis—a condition known as Parkinson’s disease dementia (PDD). Although several metaboli...
α-Synuclein positive, neuritic pathology, in the putamen of DLB and Parkinson's disease dementia (PDD), may contribute to postural-instability gait difficulty, parkinsonism, diminished levodopa responsiveness and increased neuroleptic sensitivity. Cognitive and neuropsychiatric symptoms improve with ...
The combination of dementia and parkinsonism is common and distressing, and dementia associated with Parkinson's disease (PDD) and dementia with Lewy bodies (DLB) are the most common causes. By definition, in PDD, dementia develops after more than one year with parkinsonism, whereas in DLB, dem...
(2006). Parkinson’s disease and dementia . Neurol. Sci. 27 , S40–S43. 10.1007/s10072-006-0546-6 [ Cross Ref ]Padovani, A, Costanzi, C, Gilberti, N, Borroni, B (2006) Parkinson’s disease and dementia. Neurol Sci 1: pp. S40-S43...
The neuropathology of Parkinson's disease dementia (PDD) is heterogenous, and the impact of each pathophysiology and their synergistic effects are not fully understood. The aim of this study was to evaluate the frequency of Alzheimer's disease using 18F‐florbetaben PET imaging and the impact of ...
Dementia associated with Parkinson’s disease (PDD) is a common problem and one that is associated with significant morbidity and mortality. Over the past decade, increasing research efforts and funding have been directed toward an improved understanding of PDD. Despite these efforts, fundamental gaps...
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although sharing many clinical, neurochemical and morphological features, according to DSM-5, are two entities of major neurocognitive disorders with Lewy bodies of unknown etiology. Despite considerable clinical overlap, their ...
1-3 Parkinson disease dementia affects 75% to 90% of patients who have had Parkinson disease for more than a decade,4,5 significantly reducing quality of life for both patients and caregivers.6,7 With increasing life expectancy, PDD is set to become more prevalent.8 Current therapy with ...
Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), which share many clinical, neurochemical, and morphological features, have been incorporated into DSM-5 as two separate entities of major neurocognitive disorders with Lewy bodies.