tremors, muscle stiffness, and speech impairment, among other health complications. PD, along with other neurodegenerative conditions, such as Alzheimer’s disease, causes protein build-up in neurons, leading to protein misfolding and impaired cell function. The authors ...
Parkinson's disease (PD) at cellular level is characterized by selective death of dopamine neurons in nigral pars compacta. The type of cell death remains an enigma, even though recent results suggest that apoptosis may be a common type of cell death. Since the discovery of a neurotoxin ...
It describes for commonly used cell types the aspects of Parkinson's disease they model along with technical advantages and disadvantages. It might also be helpful for researchers from other fields consulting literature on cellular models of Parkinson's disease. Important models for the study of ...
帕金森病(Parkinson's Disease,PD),是一种破坏性神经退行性疾病,影响着全球超过600万人,目前尚无治愈方法。其症状包括有节奏的颤抖、运动减慢、语言障碍和平衡问题,并且会随着时间的推移会变得更糟,这是由于中脑多巴胺神经元特异性、不可逆性丢失引起的。因此,细胞疗法被认为是一种有前景的帕金森病治疗方式,有潜力恢...
Parkinson's disease(PD) is a progressive neurodegenerative disorder,and the pathogenesis of PD is not completely understood.Establishing in vitro cell models is an important way to research the pathophysiologic mechanisms and explore new drug targets for PD treatment.关键词: Parkinson's disease cell ...
This chapter presents an overview of cell-based models and pathogenic mechanisms in Parkinson's disease (PD). The cell-based models are particularly valuable in tracking the consequences of toxin exposure and genetic mutations in a cellular environment. The advantage of cell lines is ease of genera...
Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder. Here, we demonstrate that three-dimensional (3D) differe
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Identification of PD biomarkers is crucial for early diagnosis and to develop target-based therapeutic agents. Integrative analysis of genome-scale metabolic model
Parkinson's disease researchers have used gene-editing tools to introduce the disorder's most common genetic mutation into marmoset monkey stem cells and to successfully tamp down cellular chemistry that often goes awry in Parkinson's patients.
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and no curative therapy is currently available [1]. Thus, alternative solutions are urgently needed. PD has long been considered to be among the most promising target diseases for cell replacement therapy due to the sp...