He said: ”I spend a lot of my time in the memory disorder clinic seeing geriatric patients and taking people off medications, mostly those medications that have anticholinergic properties. Many times there can be another drug out there that has less anticholinergic impact or is non-...
Nondemented status was inferred from the medical records in the remaining 3 patients, all of whom had been seen at least twice within the last year of life by a Mayo Clinic physician. Of the 13 patients with dementia, 8 had Hoehn and Yahr stage 5 disease at the end of their life, ...
Moreover. translating these nanoformulations into the clinic will require overcoming significant regulatory barriers to guarantee their safety and efficacy for patients (Đorđević et al., 2021). Addressing these challenges, would be an outstanding feat of drug delivery with improved therapeutic ...
Recent efforts have shed new light on the epigenetic mechanisms driving gene expression alterations associated with Parkinson’s disease (PD) pathogenesis. Changes in gene expression are a well-established cause of PD, and epigenetic mechanisms likely play a pivotal role in regulation. Studies in fami...
However, these approaches have been met with concerns including tumorigenicity, difficulty with resourcing of cells, high costs, and prolonged technical procedures [15,16,17], impeding the translation of these therapeutic strategies into the clinic. Emerging studies have demonstrated the feasibility of ...
PD patients will be recruited through the outpatient clinic of Beijing Rehabilitation Hospital, Capital Medical University, as well as through the hospital website. Recruitment will continue in 2023, and participants will be randomly assigned (at a 1:1 ratio) to the iTBS + PT or sham-iTBS...
In the case where an IC50 level of inhibition were to be tested, a negative outcome in the clinic could be interpreted as a need to push to higher levels of target engagement which would require additional clinical trials. One approach to mitigate this challenge could be target higher levels ...
I contacted my doctor, who, using the Neurosphere Virtual Clinic technology that controlled my Infinity DBS, was able to diagnose the problem while she was sitting in a parking lot in Paramus, New Jersey,” McNasby recalled. “I felt like it was 2250 and I was in outer space. W...
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Hence, when miRNA-based therapies are proposed, any potential perturbation(s) to other downstream pathways should be carefully analyzed, before being possibly translated into clinic [190,191]. miRNA mimics or anti-miRNAs—called antago-miRs—may represent potential therapeutic tools useful to re-...