The primary goal of this project is to conduct a pilot study for the legally mandated population-based Parkinson's disease (PD) registry in the state of California. This study is one of two linked research programs with the goals of establishing and using California PD registry data. The ...
Parkinson disease (PD) is the second most common age-related neurodegenerative condition diagnosed in North America. We recently demonstrated, using multiple epidemiological data sources, that the prevalence of PD diagnoses was greater than previously reported and currently used for clinical, research, an...
Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcrip
Tan L, Yu JT, Zhang W, Wu ZC, Zhang Q, Liu QY, Wang W, Wang HF, Ma XY, Cui WZ (2013) Association of GWAS-linked loci with late-onset Alzheimer’s disease in a northern Han Chinese population. Alzheimers Dement 9(5):546–553. doi:10.1016/j.jalz.2012.08.007 Article PubMed Goo...
Amphetamines are prescribed for the treatment of attention-deficit/hyperactivity disorder, narcolepsy, and traumatic brain injuries, and there is also growing interest in their use as cognitive enhancers. "If this is a true association and someone has a family history of Parkinson's disease, that ...
[223,224]. Increasing evidence supports the association between ghrelin disturbance and PD, and gut microbe may mediate this disturbance. Ghrelin and ghrelin receptors have significant neuroprotective effects in PD [225,226,227,228,229,230,231], and a dramatic decrease of their concentrations may ...
Other thalamic subdivisions that are among the most densely innervated by dopamine, including the midline limbic nuclei and mediodorsal and lateral posterior association nuclei44, seem to be predominantly implicated in mild PD. The pattern agrees with histopathological studies showing that the largest ...
clinical subtype (modified tremor dominant or postural instability gait difficulty), symmetry, cognitive dysfunction, depression, dysphagia, and hallucinations. Using Cox proportional hazards regression analysis, the investigators determined the association of these factors with shorter survival through December ...
and its level of expression is clearly responsive to inflammatory stimuli25. The locus has also been nominated in genome-wide association studies (GWAS) of idiopathic PD26, progressive supranuclear palsy27and several chronic inflammatory disorders28,29. As the immune system mediates a host’s respons...
Hence, these data, showing neither a positive nor a negative association of the G allele with PD, are consistent with the random occurrence of this DNA variant in the PD populations studied. These genotypic data, revealing that the nonsynonymous T1492G GLUD2 change hastens the commencement of ...