2. PD Clinical Manifestations and Disease Course 2.1. PD Definition PD is clinically defined by the presence of cardinal motor symptoms, bradykinesia in combination with at least one rest tremor or rigidity [1]. The cardinal motor symptoms depend on the progressive degeneration of the dopamine-cont...
Vitamin D Deficiency: Definition and Prevalence Role of Vitamin D in Parkinson’s Disease Vitamin D and COVID-19 in Parkinson’s Disease Vitamin D and Cancer in Parkinson’s Disease Vitamin D Supplementation in Parkinson’s Disease Future Perspectives Conclusions Author Contributions Funding Institutiona...
Background and Motivation: Diagnosis of Parkinson’s disease (PD) is often based on medical attention and clinical signs. It is subjective and does not have a good prognosis. Artificial Intelligence (AI) has played a promising role in the diagnosis of PD. However, it introduces bias due to ...
speech assessment; hypokinetic dysarthria; artificial intelligence; Parkinson’s disease; continuous speech; noisy speech; pre-diagnosis; convolutional neural networks; spectrograms; Wiener filter 1. Introduction Parkinson’s disease (PD) is a progressive neurodegenerative disorder (pathology where cells of...
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By definition, autosomal recessive (AR) inheritance suggests that the two gene alleles must be mutant for the disease to be clinically apparent, yet this is not always the case in PD [19]. Heterozygous variants in EOPD-associated genes with AR inheritance, such as PRKN and PINK1 have been ...
Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) are neurodegenerative movement disorders associated with cognitive dysfunction. The Luria’s Alternating Series Test (LAST) is a clinical tool sensitive to both graphomotor problems and perseverative tendencies that may suggest the dysfunc...
Parkinson’s disease;sexual dysfunction;hypersexuality;partnership;quality of life 1. Introduction Parkinson’s disease (PD) is a chronic, neurodegenerative disease and clinically characterized by the cardinal motor symptoms of bradykinesia, rigidity, tremor, and postural instability [1]. With a prevalen...
social actigraphy; Parkinson’s disease; dyad; cross-correlation; motor activity; rehabilitation 1. Introduction Parkinson’s disease (PD) is a chronic neurodegenerative disease affecting approximately 7 million people worldwide [1]. PD progressively affects motor capacity and cognitive functions [2], ...