Parkinson’s Disease (PD) is the second most common neurodegenerative disorder affecting primarily the survival of a specific subset of dopaminergic neurons residing in the Substantia Nigra Pars Compacta of the midbrain [1]. Most PD cases are sporadic in origin. However, a small proportion of PD...
The E3 ubiquitin ligase Parkin (PARK2) is a key regulator of the mitophagy pathway, and several forms of autosomal recessive Parkinson's disease are caused by mutations in Parkin (Ryan et al., 2015). A hallmark of mitochondrial damage is the loss of membrane potential resulting in recruitment...
Parkinson’s disease (PD) is a degenerative disease that can cause motor, cognitive, and behavioral disorders. The treatment strategies being developed are based on the typical pathologic features of PD, including the death of dopaminergic (DA) neurons in the substantia nigra of the midbrain and...
antioxidants Article Chiisanoside Mediates the Parkin/ZNF746/PGC-1α Axis by Downregulating MiR-181a to Improve Mitochondrial Biogenesis in 6-OHDA-Caused Neurotoxicity Models In Vitro and In Vivo: Suggestions for Prevention of Parkinson's Disease Yu-Ling Hsu 1,2,†, Hui-Jye Chen 1,†, ...