(×400) 表 2 TEN 对 APP/PS1 小鼠神经元内 LC3 阳性表达的 影响(x±s,n=3) Tab 2 Effects of TEN on positive distribution of LC3 in neuron of APP/PS1 mice(x±s,n=3) 组别 正常对照组 模型组 TEN 低剂量组 IOD 0.387±0.005 0.466±0.023** 0.504±0.014 组别 TEN 中剂量组 TEN 高剂量组...
Es- tablishing the driving principles underlying how PINK1/ Parkin juggle these various processes may answer many of the fundamental questions about cell-type vulnerabil- ity and disease mechanism in sPD. Furthermore, how defects in MQC may interact with other sources of neuronal vulnerability in ...
Surprisingly, we found that MFN1/2 and RHOT1 are the only detectable MOM proteins whose abundance is decreased, albeit <30%, upon depolarization in a p97-dependent manner in the context of endogenous Parkin in iNeurons. Nevertheless, p97 inhibitors do not block primary site ubiquitylation of ...