Randomized clinical trialHeart failure with reduced ejection fractionSacubitril/valsartanEnalaprilBackground: Diuretics are frequently used in patients with heart failure but can lead to neurohormonal activation, electrolyte abnormalities, and worsening renal function.Hypothesis: We hypothesized that patients ...
3. Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy[J].Okumura; Naoki;Jhund; Pardeep S.;Gong; Jianjian;Lefkowitz; Martin P.;Rizkala; Ad...
outcomes (and the effect of sacubitril/valsartan) according to etiology in the PARADIGM-HF (Prospective comparison of angiotensin-receptor-neprilysin inhibitor [ARNI] with angiotensin-converting-enzyme inhibitor [ACEI] to Determine Impact on Global Mortality and morbidity in Heart Failure) trial. ...