During participation in the PACE Plus trial, patients in the medication groups will be asked not to take paracetamol or NSAIDs because this may lead to overdose of these medications. Participant’s GP and Pharmacist will be informed about the participation of their patient in the PACE Plus tri...
1. The new guidelines recommend a two-bag acetylcysteine infusion regimen (200 mg/kg over 4 hours, then 100 mg/kg over 16 hour); this has similar efficacy but significantly reducedadverse reactionscompared with the previous three-bag regimen. 2. Massive paracetamol overdoses that result in hig...