An acute acetaminophen overdose is defined as a single ingestion of at least 7.5 g in an adult or 150 mg/kg in a child and should be considered possible in any patient who presents with a history of another overdose or altered mental status. ...
During an overdose, cytochrome P450 enzymes generate an excess of a highly toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI) (Dahlin et al., 1984; Gillette et al., 1981; Karthivashan et al., 2015). NAPQI is a highly reactive metabolite that can lead to oxidative stress, hepatocyte...
Through lipid peroxidation, the reactive species (NAPQI) produced by paracetamol overdose causes damages to hepatic cells, resulting in elevated serum levels of ALT and AST. ALT, in particular, is an important biomarker for hepatotoxicity. This is because the liver has the highest amount of the ...
To summarize, in cancer cells, DAC-paracetamol co-treatment mimics the mechanisms of paracetamol overdose (Fig. 4L), whilst cell adaptation to oxidative stress could be impaired by DAC, therefore improving the efficacy of anti-cancer drugs [36]. The specificity of the DAC-paracetamol interaction...