However, there is very little published information about the pharmacokinetics of the drug in the horse. The aim of the research was to determine the pharmacokinetics of paracetamol in equine plasma and urine to inform treatment of Thoroughbred racehorses. In this multi‐dose study, paracetamol was...
Department of Pharmacy, Heriot-Watt University, Edinburgh, UK John A. H. Forrest, J. A. Clements & L. F. Prescott Forrest, J.A.H., Clements, J.A. & Prescott, L.F. Clinical Pharmacokinetics of Paracetamol.Clin Pharmacokinet DOIhttps://doi.org/10.2165/00003088-198207020-00001 Keywords...
Onset and rate of gastric emptying are important determinants of drug absorption after oral dosing. Therefore, robust estimates of these parameters are needed in physiologically based absorption models to predict reliably plasma concentration time profiles. For human and some other laboratory animals, reas...
In Canada and the UK, the intravenous regimen for NAC is used almost exclusively; in the US, an oral regimen is used. Both regimens have been shown to be effective. There is no large scale study with direct comparison between these 2 therapeutic protocols and controversy still exists as to ...
Pharmacokinetics Paracetamol (t½ 2 h) is well absorbed from the GI tract. It is inactivated in the liver, principally by conjugation as glucuronide and sulphate. Minor metabolites of paracetamol are also formed, of which one oxidation product, N-acetyl-p-benzoquinone imine (NAPQI), is highly...
The pharmacokinetics of intrave- nous paracetamol in neonates: size matters most. Arch Dis Child 2011; 96:575-80.Allegaert K, Palmer GM, Anderson BJ. The pharmacokinetics of intravenous paracetamol in neonates: size matters most. Arch Dis Child 2011;96(6):575-580....
Background:This study evaluates the pharmacokinetics (PK) and ocular disposition of paracetamol and paracetamol glucuronide in diabetic rabbits. Methods:Thirty two New Zealand rabbits were divided into four groups: control group (I, n=8), control group with diabetes (II, n=8), rabbits with diabe...
Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use tolerabilitySummary— In 12 healthy volunteers, paracetamol pharmacokinetics were compared following administration of 1 g propacetamol HCl given intravenously over... M. Depré,A. van Hecken,R. Verbesselt,... -...
Effect of malaria infection on the pharmacokinetics of paracetamol in rat 来自 Taylor & Francis 喜欢 0 阅读量: 24 作者:Ismail, S.,Kokwaro, G. O.,Back, D. J.,Edwards, G.摘要: 1. Paracetamol (P; 50 and 300 mg/kg i.v.) was administered to the control and malaria-infected (MI) ...
Numerous studieshave confirmed the influence of diabetes mellitus on the pharmacokinetics of drugs. Paracetamol (APAP) is an antipyretic that is commonly used in febrile neutropenia (FN) therapy. APAP is chiefly metabolised by glucuronidation and sulphation. This study assessed the influence of ...