Pantoprazole(Protonix) andomeprazole(Prilosec) are proton-pump inhibitors that treat various forms of gastrointestinal discomfort, including gastroesophageal reflux disease (GERD), heartburn, stomach ulcers, and esophagitis (inflamed esophagus). Omeprazole (Prilosec) is available as an over-the-counter medi...