insulintype 2 diabetesBackgrounds: To compare the effects of insulin and oral antidiabetic drugs (OADs) on glucose control, pancreatic function, and glucose variability in newly diagnosed type 2 diabetes. Conclusions: These results indicate that insulin is probably more effective in controlling ...
Loss of pancreatic islet function and insulin-producing beta cell mass is a central hallmark in the pathogenesis of both type 1 and type 2 diabetes. While ... B Ludwig,A Barthel,A Reichel,... - Elsevier Science & Technology 被引量: 982发表: 0年 Neural hormonal regulation of exocrine panc...
Islet cell function: α and β cells – partners towards normoglycaemia Summary Under normal conditions, insulin and glucagon are counter-regulatory hormones whose balanced action exhibits a relationship that ensures normoglyca... B G?Ke - 《Int J Clin Pract Suppl》 被引量: 62发表: 2008年 ...
Secretin Pancreatic Function Test During this test you get a hormone called secretin through an intravenous (IV) line. Secretin tells your body to release digestive enzymes. Your doctor collects fluid using an endoscopic ultrasound and tests it for enzymes. If they're low, it can be a sign th...
et al. Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 54, 166–174 (2005). Article CAS PubMed Google Scholar Cnop, M. et al. Progressive loss of β-cell function leads to worsening glucose tolerance in first-degree ...
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R Li,H Huang,SW Limesand,X Chen 摘要: Chronic adrenergic stimulation is the dominant factor in impairment of the β-cell function. Sustained adrenergic exposure generates dysregulated insulin secretion in fetal sheep. Similar results have been shown in Min6 under the elevated epinephrine condition,...
Genetic manipulation of insulin action and β-cell function in mice number of genes in order to investigate the metabolic disorders that would result by manipulating insulin action or pancreatic 尾-cell function in the mouse... B Lamothe,B Duvillie,N Cordonnier,... - 《Molecular & Cellular Bio...
SC-derived islets produce insulin in response to glucose, restore normoglycemia in some animal transplant models and have been tested in phase 1 and 2 trials in humans. However, heterogeneity in endocrine cell composition and variability in function13 lead to considerable batch-to-batch variability...
insulin secretion is glucose. In addition to its trigger function, glucose also induces pathways that amplify insulin secretion through metabolism-cAMP (cyclic adenosine monophosphate) coupling or the incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic peptide (GIP).31...