ANIMALS: 74 healthy dogs and 25 dogs with EPI. PROCEDURES: A diagnosis of EPI was made on the basis of clinical signs, low serum trypsin like immunoreactivity (TLI) concentration, and response to treatment with enzyme replacement. Median values for fasting serum lipase activity and serum PLI ...
Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of digestive enzymes made by the pancreas. This disease is found frequently in dogs. EPI is also found in humans afflicted with cystic fibrosis and Shwachman-Diamond Syndrome. EPI is caused by a ...
Viviano, K. R.Ziglioli, V.Journal of Veterinary Internal MedicineVIVIANO, K. R.; ZIGLIOLI, V. Suspected isolated pancreatic enzyme deficiencies in dogs. Journal of veterinary internal medicine, v. 27, n. 3, p. 588-591, 2013.
et al. Comparison of human islet isolation outcomes using a new mammalian tissue-free enzyme versus collagenase NB-1. Transplantation 90, 255–259 (2010). Article CAS PubMed Google Scholar O'Gorman, D. et al. The standardization of pancreatic donors for islet isolations. Transplantation 80,...
Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets in sufficient quantities. Cryopreservation could solve islet supply chain challenges by enabling quality-controlled banking and pooling of donor islets. Unfor
1. An assay has been developed with sufficient sensitivity for determination of the adenosine 3':5'-cyclic monophosphate diesterase activity in islets of Langerhans, and has been used to investigate the response of the enzyme to various ... DJ Sams,W Montague - 《Biochemical Journal》 被引量...
Sometimes soybeans are given to dogs to help stimulate release of pancreatic protein digestion enzymes and get a more accurate test.The Fecal Elastase test (elastase being another digestive enzyme) is the newest test and it is only available for dogs. A single fecal sample is needed but the ...
Dobrilla G (1989) Management of chronic pancreatitis. Focus on enzyme replacement therapy. Int J Pancreatol 5:17– 29 Marotta F, O’Keefe SJ, Marks IN, Girdwood A, Young G (1989) Pancreatic enzyme replacement therapy. Importance of gastric acid secretion, H2antagonists and enteric-coating....
Lacy was able to achieve islet isolation by using an enzyme that dissociated the extracellular matrix of the tissues, composed largely of collagen, with an enzyme called collagenase. With the newly established protocol for islet isolation, Lacy opened the door for a new era of diabetes research,...
A polypeptide of the present invention may be optionally modified or partially deleted by treating it with an appropriate protein modification enzyme before or after purification. Useful protein modification enzymes include, but are not limited to, trypsin, chymotrypsin, lysylendopeptidase, protein kinase...