Recent studies reported that pancreatic β-cells are heterogeneous in terms of their transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic β-cells have been identified based on the functionality and expression of specific surface markers. Under diabetes condition...
Furthermore, hPSC secretions induced the proliferation and migration, but inhibited the apoptosis, of MiaPaCa-2 and Panc-1 cells. The proliferative effect of hPSC secretions on pancreatic cancer cells was inhibited in the presence of neutralizing antibody to platelet-derived growth factor. Our ...
12-15). Pancreatic islet cells have abundant rough ER and well-developed Golgi to produce and package their polypeptide hormones (E-Fig. 12-7). The islets contain a variety of hormone-producing cells, but this chapter is focused on the insulin-secreting β cells, which are confined to ...
PANCREAS -- SecretionsINSULINAPOPTOSISNnat) was initially identified as a selectively-expressed gene in neonatal brains, but its expression has been also identified in pancreatic β-cells. Therefore, to investigate the possible functions that Nnat may serve in pancreatic β-cells, two Nnat isotypes...
Furthermore, the inflammatory response was evaluated by quantifying splenic immune cells using ssGSEA analysis of RNA-seq results from the spleen. Compared to the mock treatment, CP-CNDS was found to significantly down-regulate almost all immune cells that have been observed, including B lymphocytes...
Peptidases, which are located on the surface of small intestinal epithelial cells, are then able to break down peptides into singleamino acids(the “building blocks of proteins”). Pancreatic proteases are secreted into the lumen of the small intestine, where they must be converted to their acti...
Prenatal exposure of embryos to valproic acid, especially during the period of organogenesis, can lead to abnormalities in the structure of the pancreas and, consequently, its function. These abnormalities occur due to defects in proliferation and differentiation in pancreatic cells during embryonic devel...
The pathophysiology of acute pancreatitis is multifaceted, centered around the premature activation of digestive enzymes within the pancreas, leading to autodigestion and a cascade of inflammatory responses. This process begins with the activation of trypsinogen to trypsin within the acinar cells, rather ...
Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose escalation and expansion, trial for patients with advanced, unresectable PDAC ...
The triggering pathway to insulin secretion: functional similarities and differences between the human and the mouse beta cells and their translational relevance. Islets. 2017;9:109–39. 57. Zschaler J, Schlorke D, Arnhold J. Differences in innate immune response between man and mouse. Crit Rev...