2a and b). The GCaMP6f expressing cells responded to both NE and glutamate stimulation, while the RCaMP1.07 expressing cells were silent under both stimuli. These data both reinforced the expression specificity of α and β cells, and non-detectable overlaps in emission spectrums between GCaMP6...
Recent studies reported that pancreatic β-cells are heterogeneous in terms of their transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic β-cells have been identified based on the functionality and expression of specific surface markers. Under diabetes condition...
• Normally these cells release inactive enzymes into col- lecting ducts, which then drain into the main or accessory pancreatic ducts, emptying directly into the duodenal lumen. • In the presence of obstruction or disruption of the pancre- atic ducts, the pancreatic secretions are activated ...
Pancreatic insufficiencyis caused by the progressive depletion of pancreaticacinar cells. It is defined as an insufficient amount ofpancreatic enzymesresulting insteatorrheaand fatmalabsorption. The pancreas has a large reserve capacity and fat malabsorption does not occur untilenzyme secretionis reduced by...
cells[1]. Approximately 1 million islets are distributed throughout the human pancreas[2]. Islets consist of up to five different hormone-secretingendocrine celltypes, including the glucagon-producing alpha cells, the insulin-producing beta cells, and somatostatin-producing delta cells (Figure 1)[3...
Some reports showed that short-term kisspeptin exposure can inhibit GSIS in isolated pancreatic cells12,13,15. Although the indirect effects of kisspeptin on the insulin secretions of α and δ cells have been ruled out, it remained unclear how kisspeptin directly affected insulin secretion of β ...
Peptidases, which are located on the surface of small intestinal epithelial cells, are then able to break down peptides into singleamino acids(the “building blocks of proteins”). Pancreatic proteases are secreted into the lumen of the small intestine, where they must be converted to their acti...
After confirming lack of autocrine effects of ELR+-CXC-chemokines on PaCa cells (due to absence of CXCR2 expression), we investigated paracrine effects of these chemokines on human umbilical vein endothelial cells (HUVEC). Both recombinant ELR+-CXC-chemokines and co-culturing with BxPC-3 ...
The long lasting increase in pancreatic serous secretion would be consistent with the possible activation of gene transcription by taurocholate leading to increased activity of the Na/K/2Cl cotransporter through which the acinar cells increased their secretions....
3.1.1 Etiology and Prognosis Some AP-triggering environmental toxins are known to directly affect pancreatic acinar cells, leading to rupture and necrosis, and eventually an extensive inflam- matory response. Epidemiological studies have revealed that the morbidity rate of the disease depends on which...