Endocrine pancreas: mechanisms of insulin secretion by the β-cells; interactions among insulin, glucagon and somatostatinThe endocrine pancreas is composed of the islets of Langerhans which comprise approximately two million clusters of cells dispersed within the acinar tissue of the exocrine pancreas. ...
Secretion of insulin by the canine pancreas perfused ex vivo with fluorocarbon emulsion. 来自 NCBI 喜欢 0 阅读量: 24 作者:K Kowalewski,A Kolodej,M Kocylowski 摘要: Canine gastroduodenopancreatic blocks were isolated and perfused ex vivo with oxygenated bloodless emulsion. Pancreatic and gastric ...
Lack of direct inhibition of insulin secretion by exogenous insulin in the canine pancreas. To test whether insulin secretion is self-regulatory, canine pancreata were isolated and perfused in vitro and were infused with 0.3, 0.6, or 1.2 mU/ml exogenous insulin. Basal and arginine-stimulated conc...
Also, caloric restriction, which decreases daily insulin secretion, inhibits pancreatic cancer induction in hamsters (Roebuck et al., 1993). Conversely, high-fat–fed hamsters have increased insulin levels but normal glucose levels and subsequently increased islet cell proliferation and pancreatic ...
SP cells were flow sorted from dissociated pancreas cells of adult mice, analysed for phenotype and cultured with growth promoting and differentiation factors before analysis for hormone expression and glucose-stimulated insulin secretion. SP cell number and colony forming potential (CFP) increased ...
While numerous techniques can be used to measure and analyze insulin secretion in isolated islets in culture, assessments of insulin secretion in vivo are typically indirect and only semiquantitative. The CpepSfGFP reporter mouse line allows the in vivo
Pancreatic secretion and hepatic removal of insulin remained unchanged by the TAA-treatment. Thus, even in morphologically and biochemically proven experimental liver cirrhosis, insulin secretion and removal may not be disturbed.关键词: Insulin Liver Pancreas Rat Thioacetamide Cirrhosis ...
Activation of nestin-positive duct stem (NPDS) cells in pancreas upon neogenic motivation and possible cytodifferentiation into insulin-secreting cells fro... In addition, insulin secretion from these beta cells responded to glucose stimulation. We found transient up-regulation of PDX-1 expression by...
PENs can be divided into neoplasms that are functional (i.e., associated with a specific clinical syndrome and appropriate hypersecretion of a hormonal product, such as insulin or glucagon) and neoplasms that are nonfunctional (see Fig. 11.11C). Given the rarity of PENs, attempts at molecular...
More information:"Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion"Science,