The mammalian hedgehog proteins sonic (Shh), indian (Ihh), and desert (Dhh) have distinct functions in the regulation of embryonic pancreas development compared with later functions in the maintenance of pancreatic 尾-cell mass and the regulation of insulin production. In adult pancreatic islets,...
Dictionary, Encyclopedia and Thesaurus - The Free Dictionary13,776,365,103visits served TheFreeDictionary Google ? Keyboard Word / Article Starts with Ends with Text EnglishEspañolDeutschFrançaisItalianoالعربية中文简体PolskiPortuguêsNederlandsNorskΕλληνικήРусский...
Pancreatic islets from HD transgenic mice express reduced levels of the pancreatic islet hormones insulin, somatostatin, and glucagon and exhibit intrinsic defects in insulin production. Intranuclear inclusions accumulate with aging in transgenic pancreatic islets, concomitant with the decline in glucose ...
Pancreas, compound gland that discharges digestive enzymes into the gut and secretes the hormones insulin and glucagon, vital in carbohydrate (sugar) metabolism, into the bloodstream. In humans the pancreas weighs approximately 80 grams (about 3 ounces)
The total absence or low production of insulin by beta-cells avoids a proper control of glycemia forcing diabetic people to daily insulin injection for survival. Islet transplantation represents a hallmark in the cure of diabetes and has been successfully applied to more than 400 patients, resulting...
Diabetes is a serious lifelong disease, always characterized by abnormally high blood glucose levels due to insulin production disorder or decreased insulin sensitivity and function [1]. Type 1 diabetes (T1D) is an autoimmune disorder that leads to the destruction of pancreatic β-cells and occurs...
Irreversible and permanent diabetes was induced by streptozotocin. Graft function was assessed by measuring glucose tolerance and insulin production during an i.v. glucose tolerance test. The fractional growth rate of the transplanted host was used to evaluate the long‐term consequence of...
Plasma levels of glucose and insulin were measured during the oral glucose tolerance test (2.0g/kg, for 180 min) in six children who had undergone caudal pancreatectomy for panceatic trauma or non-functioning tumors. Fasting plasma levels of glucose and insulin were the same in these patients ...
More critically, both uniform size assumptions (U/U and U/R) severely underestimate the more important downstream effects of hypoxia on cell survival and insulin secretion. For example, assumptions U/U and U/R suggest >8-fold lower levels of the expected loss of function compared to SHARP (...
Insulin-producing cells, however, were more numerous than glucagon-producing cells. This ratio was unchanged with cold acclimation. Immunoreactivity of α and β cells was more intense in cold-acclimated than in thermoneutral animals, possibly indicative of a change in hormonal production in animals ...