Given the current lack of an effective treatment, we aimed at characterizing the effects of the pan-peroxisome proliferator-activated receptors (pan-PPAR) agonist lanifibranor in two pre-clinical models of ACLD, as well as in liver cells from patients with ACLD. Methods Cirrhotic rats (...
Lanifibranor is a pan-PPAR agonist with balanced α, β/δ, and γ activity29. It has a distinct chemical structure from other PPAR agonists and a unique pattern of co-activator or -repressor recruitment upon ligand binding30. These characteristics comprehensively address MASH biology and make l...
Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension Tu L, Luccarini JM, Junien JL, Broqua P, Allanore Y (2017) Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertensi... J Avouac,I Konstantinova,C Guignabert,... ...
Myelin Disruption, Neuroinflammation, and Oxidative Stress Induced by Sulfite in the Striatum of Rats Are Mitigated by the pan-PPAR agonist Bezafibrate. Cells. 2023; 12(12):1557. https://doi.org/10.3390/cells12121557 Chicago/Turabian Style Glänzel, Nícolas Manzke, Belisa Parmeggiani, Mateus...
尽管在许多肾脏疾病中,PPAR-α都表现出保护作用,但是其在氨基核苷嘌呤霉素(PAN)诱导的大鼠肾小球足细胞损伤中的作用报道较少。因此,我们拟通过建立PAN大鼠肾小球足细胞损伤模型,以尿蛋白水平的上升和足细胞损伤标志物desmin的表达上调作为成模型标准,通过PPAR-α特异性激动剂非诺贝特予以治疗,探索PPAR-α激动剂非诺贝特...
Due to the undesirable side-effects, many PPAR agonists including PPARα/γ and PPARβ/γ dual agonists are stopped by US FDA in the clinical trials. An alternative strategy is to design novel pan-agonist that can simultaneously activate PPARα, PPARβ and PPARγ. Under such an idea, in ...
This improvement resulted in increased OXPHOS activity and finally in enhanced mitochondrial ATP generating capacity. PPAR panagonists are known to increase the expression of PPAR gamma coactivator-1α (PGC-1α), a master regulator of mitochondrial biogenesis. Acc 展开 ...
These compounds, as selective agonists activating peroxisome proliferator-activated receptors (PPAR), in particularly the RXR/PPARalpha, RXR/PPARgamma, and RXRJPPARdelta heterodimers, are useful in the treatment and/or prevention of type 2 diabetes and associated metabolic syndrome such as hypertension...
pan‐cancerPeroxisome proliferator‐activated receptors (PPARs) are a family of nuclear receptors that regulate lipid metabolism and bioenergetic demands within living systems. Consequently, aberrant expression of PPAR genes could predispose individuals to diseases, including cancer. PPAR signaling exerts ...
Scaffold-BasedPan-AgonistDesignforthePPARa,PPARb andPPARcReceptors Li-SongZhang 1. ,Shu-QingWang 1. ,Wei-RenXu 2 ,Run-LingWang 1 *,Jing-FangWang 3,4 * 1TianjinKeyLaboratoryonTechnologiesEnablingDevelopmentofClinicalTherapeuticsandDiagnostics(Theranostics),SchoolofPharmacy,TianjinMedicalUniversity, Tianj...