Chemical structures of lysyl oxidase family catalyzed hydroxyallysine or allysine residues and the subsequent divalent and trivalent bonds that are formed that can be quantified by mass spectrometry. c. Representative images of 3D organotypic matrix contraction by human pancreatic cancer CAFs at days 2...
乙酰基赖氨酸/乙酰化赖氨酸抗体(Acetylated Lysine) 价格: ￥1980/支 产品详情:科淼生物简介温州科淼生物科技有限公司(Whenzhou KeMiao Biological Technology Co.,Ltd)是一家专业从事“产品研发生产,市场销... 纯度:1mg/ml% 包装规格:100ul 用途:仅供科研使用 用途:仅供科研使用 货号:KMA029062R 品牌:KEMOBio...
C Curtet,F Maton,T Havet,M Slinkin,A Mishra,JF Chatal,RN Muller.Polylysine-Gd-DTPAn and polylysine-Gd-DOTAn coupled to anti-CEA F(ab′)2 fragments as potential immunocontrast agents. Relaxometry, biodistribution, and magnetic resonance imaging in nude mice grafted with human ...
Biotin-poly-L-Glutamicacid/Biotin-pGlu Biotin-Poly-L-lysine/Biotin-PLL Biotin-Poly-L-lysineBiotin-PLL Bis-MPAAmmoniumDendrimer(可选1-4代) bis-MPA-COOHdendrimer-doped bis-MPA-COOHdendrimer-dopedAgCl bis-MPA-p-TSA Bis-MPAAmmoniumDendrimer-mPEG Bis-MPAAmmoniumDendrimer-PCL-mPEG Bis-MPAAmmoniumDendr...
[22,54,55,56]. Through screening and integration of Sp1-interacting proteins and the most relevant Sp1-associated genes, we identified two intersecting genes, CREBBP and EP300. CREBBP and EP300 are well-known homologous lysine acetyltransferases frequently mutated in hematological malignancies and ...
Panobinostat is a novel cinnamic hydroxamic acid pan-deacetylase inhibitor able to induce hyperacetylation of lysine residues on both histone and non-histone targets in cancer cells. Panobinostat is currently in clinical development, as both an intravenous and oral formulation, across multiple tumor type...
Recently, oncogenic rearrangements involving Lysine methyltransferase 2A (KMT2A), a frequent fusion partner in some acute leukemias, have been reported in solid tumors, including types B2 and B3 thymomas and soft tissue sarcomas [3,4,5,6,7]. Yoshida et al. first described two soft tissue ...
CREBBP and EP300 are well-known homologous lysine acetyltransferases frequently mutated in hematological malignancies and have become promising drug targets [57, 58]. However, there is a lack of studies focusing on the mechanism connecting Sp1 and CREBBP/EP300 in different cancers. Through GSEA ...
Again, the lysine acetylase domain, KAT11, was identified with high entropy for a significant hotspot at position 94 of the domain alignment with mutations in EP300 at D1399 and CREBBP at D1435 (Table 2, row 1). These sites are located in the substrate binding loop of KAT11, and ...
et al. Role of histone H3 lysine 27 methylation in X inactivation. Science 300, 131–135 (2003). 5. Gupta, R. A. et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464, 1071–1076 (2010). 6. Carrieri, C. et al. Long non-coding ...