可以使用核磁共振(NMR)、红外光谱(IR)、质谱(MS)等方法对DOTA缀合的PAMAM G4树枝状聚合物进行结构表征。 通过测定其溶解度、粒径、电荷等性质,可以进一步了解该材料的性能和应用潜力。 注意:用途仅用于科研,以上来自小编wyh 相关产品 DOTA-FA-FITC-G5 NHAc 异硫氰酸荧光素-叶酸-DOTA修饰第5代(G5)聚(酰胺基...
In this research, the anti-cancer efficacy of oxaliplatin was modulated using a nanocarrier system with enhanced targeting efficacy towards FAR expressing colorectal cancer cells. Oxaliplatin was loaded into G4 imprinted with PEG and FA. The nano-complexes were characterized by FT-IR, 1 H NMR, ...
~1H NMR and NOESY spectroscopyCircular dichroismInteractions between electromagnetic radiation and the side substituents of aromatic amino acids are widely used in the biochemical studies on proteins and their interactions with ligand molecules. That is why the aim of our study was to characterize the ...
Abstract Interactions between PAMAM-NH2 \\{G4\\} dendrimer and paracetamol in aqueous solutions were examined by \\{UV\\} spectroscopy, equilibrium dialysis, 1H \\{NMR\\} spectroscopy and calorimetric techniques. The results of equilibrium dialysis show that PAMAM-NH2 \\{G4\\} dendrimer can ...
Interactions between PAMAM-NH_2 G4 dendrimer and paracetamol in aqueous solutions were examined by UV spectroscopy, equilibrium dialysis, ~1H NMR spectroscopy and calorimetric techniques. The results of equilibrium dialysis show that PAMAM-NH2 G4 dendrimer can combine 18 paracetamol molecules with ...
1H NMR showed a disappearance of the proton amine group signals, correlating with docking results. MALDI-TOF and atomic force microscopy suggested the drug-G4 PAMAM dendrimer complexes formation. Discussion: In vitro studies showed that G4 PAMAM has toxicity in the micromolar concentration in MDAMB...
1HNMR measurements show that the dendrimer macromolecule binds the drug molecules with superficial protonated or unprotonated amine groups.Adam Buczkowski and Pawel Urbaniak and Bartlomiej PaleczInternational Journal of PharmaceuticsA. Buczkowski, P. Urbaniak, B. Palcez, Thermochemical and spectroscopic ...
In this study, special attention was paid to the correlation between the degree of ionization of the components and the effective formation of the complex under alkaline conditions. Using UV-Vis, 1H NMR, and CD, structural changes of the drug depending on the pH were monitored. In the pH ...
The formation of G4-PAMAM-peptide complexes was evaluated in silico (molecular docking studies using different G4-PAMAM conformations retrieved from MD simulations as well as the MMGBSA approach) and validated experimentally (electrophoresis, 1H NMR and cryo-TEM). Next, the G4-PAMAM dendrimer-...
H-1 NMR spectroscopyIsothermal titration calorimetryThe macromolecule of PAMAM-NH2 G4 dendrimer can combine up to 18 paracetamol molecules.PAMAM-NH2 G4 molecule has two sets of active sites that bind paracetamol (PC).Stoichiometry and equilibrium constants of the G4–PC complex were determinedThe ...