(2006). Stereoselective to- tal synthesis of serine palmitoyl-CoA transferase inhibitors. Synthesis, 2006, 2447-2474. DOI: 10.1055/s-2006-942475.Byun, H.-S., Lu, X., Bittman, R. (2006) Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors. Synthesis 15: pp. 2447-...
3). Palmitoyl-CoA, a substrate for CPT-I, is also a preferred substrate for ceramide synthesis de novo. Paumen et al.26 have observed that pharmacological inhibition of CPT-I results in: (1) an accumulation of palmitate in the cytoplasm; (2) an increase of ceramide synthesis; and (3) ...
In our system it was not possible to add GTP, a potent stimulator of the acyl-CoA independent activity, as done earlier (6) since GTP interfered with the synthesis of [3H]MPD from GDP-[3H]mannose. It is also possible that the acyl-CoA independent activity does not recognize dioctanoyl ...
(2006) Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors. Synthesis 15: pp. 2447-2474Byun, H.-S., Lu, X., & Bittman, R. (2006). Stereoselective to- tal synthesis of serine palmitoyl-CoA transferase inhibitors. Synthesis, 15, 2447-2474. DOI: 10.1055/s-2006-...
ASYMMETRIC-SYNTHESISAMINO-ACIDSThis review summarizes the total syntheses of the fungal metabolites mycestericin, myriocin, viridiofungin, sulfamisterin, and sphingofungin. The syntheses are organized into three sections: the preparation of (a) the long chain and (b) the polar head group, and...
One of the β-keto esters prepared using this method was ethyl 3-oxohexadecanoate, a key intermediate in the synthesis of 3-ketopalmitoyl coenzyme A (3-oxohexadecanoyl coenzyme A), a potential substrate of the biologically important enzyme 17β-hydroxysteroid dehydrogenase type 12....
Human and murine serine-palmitoyl-CoA transfer- ase-cloning, expression and characterization of the key enzyme in sphin- golipid synthesis. Eur J Biochem. 1997;249:239-247.Weiss B, Stoffel W. Human and murine serine-palmitoyl-CoA trans- ferase: cloning, expression and characterization of the ...
doi:10.1002/chin.201241075Urban KosakAndreja KovacStanislav GobecWILEY‐VCH VerlagKosǎ k, U.; Kovac,̌ A.; Gobec, S. One-Pot Synthesis of β-Keto Esters and Preparation of 3-Ketopalmitoyl-CoA. Synlett 2012, 23 (11), 1609-1612....
Stoffel, Human and murine serine-palmitoyl-CoA trans- ferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis, Eur. J. Biochem. 249 (1997) 239 - 247.Bertram Weiss et al., Human and murine serine-palmitoyl-CoA transferase, Eur. J. biochem., vol. 249:...
Overall, the effect ofMrACBP2 on the synthesis of fatty acid andMonascuspigment was explored. This paper explored the effect ofMrACBP2 on the fatty acid synthesis and the synthesis ofMonascuspigment. The results indicated the regulation of fatty acid synthesis could affectMonascuspigment synthesis,...