在体外研究中,为了模拟2型糖尿病所致的器官损伤,除在细胞培养基中添加高浓度的葡萄糖外,通常需要添加高浓度的棕榈酸钠(Palmitic acid)和/或油酸钠(sodium oleate),这是因为软脂酸是存在于动物、植物及微生物中最常见的饱和脂肪酸。 正常情况下,人体血液中软脂酸的浓度均值约为100umol/L,肥胖和2型糖尿病情况下血液中软脂酸浓度
Palmitic acid is a type of fatty acid that is poorly incorporated into TAG pools and can lead to the accumulation of ceramides and apoptosis. It has been found to be lipotoxic in certain cell models and can be prevented by the overexpression of SCD1, an enzyme that promotes the synthesis ...
Fatty acid uptake and altered metabolism constitute hallmarks of metastasis1,2, yet evidence of the underlying biology, as well as whether all dietary fatty acids are prometastatic, is lacking. Here we show that dietary palmitic acid (PA), but not oleic acid or linoleic acid, promotes metastasis...
We further investigated the effects of palmitic acid (PA) because it is the most abundant saturated FFA in human Discussion IP-10 is a member of the CXC chemokine family, which includes other factors such as MIG, I-TAC, IL-8, and MIP-2, and is produced by a variety of cell types, ...
We identified that metabolic enzyme acyl-CoA oxidase 1 (ACOX1) suppresses colorectal cancer (CRC) progression by regulating palmitic acid (PA) reprogramming. ACOX1 is highly downregulated in CRC, which predicts poor clinical outcome in CRC patients. Functionally, ACOX1 depletion promotes CRC cell ...
2.1 with different concentrations of palmitic acid on the basis of INS-1 cells in dynamic changes of insulin secretion of INS-1 cells at 0.1mmol / L, 0.2mmol / L, 0.3mmol / L, 0.4mmol / L of palmitic acid in the complete culture INS-1 cell culture-based 6h, basal insulin sec...
货号: sigma Palmitic acid棕榈酸 P5585-10G 英文名称: Sigma-Aldrich, Fluka 保质期: 10年 个月 保存条件: 低温 Sigma-Aldrich 是*的生命科学与高科技集团公司。我们的产品被广泛地应用于生命科学、有机化学、材料科学、分析化学与其他高科技的研发及生产。我们的用户遍及生命科学公司、大学与政府研究机构与...
Article https://doi.org/10.1038/s41467-024-45582-8 Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling Received: 26 June 2023 Accepted: 26 January 2024 Check for updates Xiqiang Wang1,5, Ling Zhu1,5, Jing Liu1, Yanpeng Ma1, ...
Notably, OGT inhibition by its antagonist (ST045849) suppressed cell proliferation in vitro (p <0.001) and in xenograft mice models (p <0.05). Conclusions OGT plays an oncogenic role in NAFLD-associated HCC through regulating palmitic acid and inducing ER stress, consequently activating oncogenic ...
Palmitic acid biochemistry, trafficking, and metabolites Exogenous, meal-derived palmitic acid Followingintestinal absorption,short chain FA(SCFA, <6C),medium chain FA(MCFA, 6–12 C) andlong chain FA(LCFA, >12 carbons) are transported in the body differently. The majority of SCFAs are transported...