The solubility of this compound in DMSO is >28.7mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. ...
Solubility:Soluble in DMSO, not in water Shelf Life:>2 years if stored properly Drug Formulation:This drug may be formulated in DMSO Stock Solution Storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). ...
This orally active, non-ATP-competitive cyclin kinase-directed inhibitor (FW = 483.99 g/mol (mono-HCl); CASs = 827022-32-2 (mono- hydrochloride, 571190-30-2 (free base); Solubility: 10 mg/mL DMSO; 30 mg/mL Water; Formulation: Dissolved in sodium lactate buffer (50 mM, ® pH 4.0...
Palbociclib is a poorly water-soluble medicine which acts against metastatic breast cancer cells. Among various techniques to improve the solubility of this medicine, applying supercritical technologies to produce micro- and nano-sized particles is a possible option. For this purpose, extraction of ...
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the la...
Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions. In this study, two cocrystals of PAL with resorcinol (RES) or orcinol (ORC) were prepared...
Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. Palbociclib (PD-0332991) HCl Chemical Structure CAS No. 827022-32-2 ...
溶解性Solubility (25°C) * 二甲基亚砜DMSO Insoluble 水Water 10 mg/mLwarmed(17.43 mM) 乙醇Alcohol Insoluble 制备储备液 浓度 溶剂体积(DMSO) 质量 1 mg 5 mg 10 mg 1 mM 1.7432 mL 8.7160 mL 17.4319 mL 5 mM 0.3486 mL 1.7432 mL 3.4864 mL 10 mM 0.1743 mL 0.8716 mL 1.7432 mL 50 mM 0.0349...
Enzyme inhibitor This orally active, non-ATP-competitive cyclin kinase-directed inhibitor (FW = 483.99 g/mol (mono-HCl); CASs = 827022-32-2 (mono- hydrochloride, 571190-30-2 (free base); Solubility: 10 mg/mL DMSO; 30 mg/mL Water; Formulation: Dissolved in sodium lactate buffer (50 mM...
Compared with a crystal form A and a crystal form B, the crystal-type palbociclib free-alkali hydrate Form I has good storage stability, and meanwhile the solubility of the crystal-type palbociclib free-alkali hydrate Form I in water and polar solvent is significantly improved compared with the...