A series of recent studies report novel roles for Pak1, a key member of the highly conserved family of serine-threonine protein kinases regulated by Ras-related small G-proteins, Cdc42/Rac1, in cardiac physiology and cardioprotection. Previous studies had identified Pak1 in the regulation of hy...
Transient transfection studies demonstrated that LPS represses SR-BI promoter activity in the macrophage cell line RAW 264.7. Cotransfection with either a constitutively active p21-activated protein kinase-1 (PAK1) construct (T423E) or a kinase-deficient PAK1 construct (K299R) resulted in ...
P Del Río,X Labandeira - 《Environmental Economics & Policy Studies》 被引量: 26发表: 2009年 Analyzing China Harmonization of Technical Barriers to Trade in the EU and US Markets As the course of economy glohalization and trade liberalization have been speeding up,the protective in the interna...
Correlation of PAK-1 and DPC4 expression, suggests that PAK-1 expression may be associated with TGF-尾 signaling and has a different role in PDA compared to breast and colorectal cancers. Further studies are needed to explore the role of PAK-1 in PDA....
Nef proteins from human immunodeciency virus type 1 (HIV-1) and simian immunodeciency virus (SIV) have been found to associate with an active cellular serine/threonine kinase designated Nef-associated kinase (Nak). The exact identity of Nak remains controversial, with two recent studies indicatin...
Latest case studies Optimising plant-based cheese production Make every ingredient count and deliver tasty cheese products your customers will love. All the principles for plant-based cheese production are right here. Download the plant-based cheese production white paper ...
Studies on the medicinal plants of Ayvacik-Çanakkale in Turkey A total of 117 taxa belonging to 42 families were collected from the Ayvacik city of Canakkale. Out of these 43 taxa were observed to be used for medicinal... I Uysal,S Gücel,T Tütenocakli,... - 《Pakistan Journal of ...
Thus, further studies of the integrin 1–integrin-linked kinase-pAkt signaling pathway may provide a novel prognostic marker and therapeutic target for non–small cell lung cancer. 展开 关键词: Integrin 1 Phospho-Akt Lung cancer DOI: 10.1016/j.humpath.2007.01.003 被引量: 183 ...
Although K-Ras, Cdc42, and PAK4 signaling are commonly deregulated in cancer, only a few studies have sought to comprehensively examine the spectrum of phosphorylation-mediated signaling downstream of each of these key signaling nodes. In this study, we completed a label-free quantitative analysis...
Further studies with this antibody and a PAK2-specific antibody against the N-terminal region of PAK2 demonstrate that hyperosmotic shock can induce cleavage of PAK2 to generate a 36 kDa C-terminal catalytic fragment in cells. The cleavage and activation of PAK2 was found to be closely ...