Slow IPSC kinetics, low levels of alpha1 subunit expression and paired- pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus. Eur J Neurosci. 2001; 13:2088-2098. [PubMed: 11422449]...
采用双脉冲刺激比率(paired-pulse ratio,PPR,一个用于验证突触前递质释放概率变化的电生理指标)的实验证实,SNL小鼠NAc壳区MSNs记录到的EPSCs的PPR值显著增加,IPSC的PPR值减小。 前期研究显示,SNL引起的神经病理性疼痛同时也导致NAc区趋化因子CCL2及受体CCR2表达和活动增加,并且参与MSN兴奋性突触传递效率的调节。为了进...
Characterization of paired pulse ratio (PPR) of evoked IPSC during SD.Isamu AibaC. William Shuttleworth
Slow IPSC kinetics, low levels of alpha 1 subunit expression and paired pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the superior colliculus. Eur J Neurosci. 2001; 13 :2088–2098.Jüttner R, Meier J, Grantyn R (2001) Slow IPSC kinetics, low...
Mean paired-pulse ratio was also affected鈥攚e observed facilitation of second IPSC in low-calcium whereas the latter was depressed in high-calcium solution. Our results suggest that calcium concentrations not only regulate the strength of paired-pulse plasticity but also can invert its direction....