Paired Pulse Facilitation(PPF)原理是指在神经元突触上,两个紧随其后的短暂刺激会导致第二个EPSP(兴奋性突触后电位)幅度增大,而非衰减的现象。这是由于第一个刺激引起的钙离子内流并未完全耗尽,反而暂时增强了突触前终末对钙离子的敏感性,使得第二个刺激引起的神经递质释放增多,从而增强了突触传递效率。PPF是研究...
Paired-pulse facilitation (PPF)Inverse PPFModern technology allows us to mimic biological functions with artificial devices. The human brain, including numerous neural cells that connect via synapses, enables us to handle complex tasks with ultra-low power consumption, which is one of the most ...
1PairedPulseFacilitation(PPF)orDepression(PPD)5 1.1AimofExperiment5 1.2Preparations6 1.3TriggeringMC_RackontheStimulus7 1.4ExtractingthePeaktoPeakAmplitude8 1.5DefiningtheRegionofInterest9 1.6DefiningtheSecondRegionofInterest10 1.7PlottingAmplitudeversusTime11 ...
类型 配对脉冲刺激具有两种相反的反应类型:双脉冲易化(paired-pulse facilitation;PPF)和双脉冲抑制(paired pulse depression;PPD)(如图2)。Bryan Krause认为在这两种反应中,第二次脉冲后的钙浓度都高于第一次脉冲后的钙浓度。 图2 来源:参考资料[1] paired-pulse facilitation,PPF,双脉冲易化 当施加两个连续脉冲时...
(b) A bar chart showing percentage paired-pulse facilitation (PPF) both pre- and post-LFS for ISIs of50 and 100 msec. Note the increase in facilitation at both ISIs. (c) Examples offEPSPs displaying PPF for both ISis (the right-hand traces are post-LFS). Calibration bars represent 0.5...
Paired-pulse facilitation (PPF) is a form of short-term plasticity which has been used qualitatively to characterize the action of neuroactive compounds. The aims of the present study were to develop a model that allows the quantitative assessment of PPF and to evaluate the influence of CNQX, ...
Here we show that, using extracellular recording from frog cutaneous pectoris muscle, paired-pulse facilitation (PPF) at the frog neuro-muscular junction decays in two or three-exponential manner depending upon the extracellular Ca 2+ concentration ([Ca 2+ ] e ). First, second and "early" ...
It has been hypothesized that if LTP expression includes a presynaptic locus then it may alter the expression of another presynaptically mediated form of potentiation like paired-pulse facilitation (PPF), which is an increase in a second population excitatory postsynaptic potential when it is elicited...
The technique of paired-pulse test combined with electrophysiology and behavioral learning was used to examine the effect of behavioral long-term potentiation(LTP) on paired-pulse facilitation( PPF) efficacy at hippocampal MF-CA3 synapses after behavioral learning. The results showed that in baseline(...
Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. J. Neurophysiol. 78: 2707-2716, 1997. The relationship between paired-pulse facilitation (PPF) and synaptic potentiation induced by various protocols and their cellular and molecular mechanisms...