General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating supraspinal analgesic circuits. We discovered a distinct population of GABAergic neurons...
(SNR). SNR-projecting LPB neurons are activated by noxious stimuli and silencing them blocks pain responses in two different models of pain. LPB-targeted and nociception-recipient SNR neurons regulate VTA DA activity directly through feed-forward inhibition and indirectly by inhibiting a distinct ...
Side effectsPalliation of bone metastases (BM) comprises a significant proportion of the workload in the specialty of radiation oncology. About 50% of cancer patients will receive palliative radiotherapy (RT) during the course of their disease. Seventy percent of BM occur in the axial skeleton ...
If we look at the joint side, it has been observed that mast cells are dispersed in varying patterns inside osteophytes and knee synovial fluid, potentially exacerbating the inflammatory pathophysiology of osteoarthritis [56]. This led researchers to introduce a novel classification system for the ...
Affecting one in five people, chronic pain is a complex, multifactorial condition that is challenging for both patients and clinicians. Prevailing pain management, which includes NSAIDS and opioids, has not adequately addressed the growing cohort of those suffering and comes with serious side effects...
BACKGROUND:Interindividual variability in pain perception and analgesic response is a major problem in perioperative practice. Adult studies suggest pain m... S Sadhasivam,V Chidambaran,P Ngamprasertwong,... - 《Pediatrics》 被引量: 86发表: 2012年 Race and unequal burden of perioperative pain ...
Future directions in research, treatment and prevention of HPV-related squamous cell carcinoma of the head and neck. An important aim of novel approaches for favorable-prognosis, HPV-associated cancers will be minimization of devastating side effects of intensified treatment ... A Psyrri,C Sasaki,...
expression recognition in ASD individuals13. Explicit empathy is typically considered as conscious and controlled processing, while implicit empathy is typically considered to be a more automatic occurrence outside of the conscious awareness14. Furthermore, it has been suggested that top-down attention ...
Patiño-Camacho SI, Déciga Campos M, Beltrán-Villalobos K, Castro-Vidal DA, Montiel-Ruiz RM, Flores-Murrieta FJ. Low doses of tizanidine synergize the anti-nociceptive and anti-inflammatory effects of ketorolac or naproxen while reducing of side effects. Eur J Pharmacol. 2017;805:51–7. ...
There has been increased interest in the role that sex and gender have in the perception and experience of pain. The general finding is that women experience more pain when compared to men. The aim of this chapter will be to provide readers with an overv