综上所述,该研究表明,PAF和Tr-oxPLs(也称为PAF-LPLs)能够引发和传播铁死亡,这导致AKI期间的肾小管损伤。通过给予PAFAH2或通过针对PAF和类似PAF分子的中和抗体对PAF和PAF-LPLs进行解毒,可能会预防多种急性器官损伤和相关的系统性多器官衰竭。
显微注射PAF至培养细胞或分离的原代肾小管的能促进临近细胞死亡或“wave-like cell death”，而特异结合PAF的中和抗体能有效抑制铁死亡的发生。这些结果表明，PAF是细胞执行铁死亡的重要分子，并通过分泌到细胞外感染其邻近的细胞，促进铁死亡在细胞群体中传播。血小板激活因子乙酰水解酶2（PAFAH2）是细胞内能特异性水解PA...
PAF乙酰水解酶(II)(PAFAH2)对铁死亡同步肾小管细胞死亡、肾单位丢失和AKI具有保护作用。 研究背景: 铁死亡是一种受调节的坏死细胞死亡过程,其特征是铁依赖性脂质氢过氧化物的积累。在铁死亡过程中,脂质代谢和铁代谢与氧化还原调节系统交叉。与其他形式的坏死不同,铁死亡倾向于影响功能单元,而不是随机影响单个细胞。这...
显微注射PAF至培养细胞或分离的原代肾小管的能促进临近细胞死亡或“wave-like cell death”,而特异结合PAF的中和抗体能有效抑制铁死亡的发生。这些结果表明,PAF是细胞执行铁死亡的重要分子,并通过分泌到细胞外感染其邻近的细胞,促进铁死亡在细胞...
Synchronized ferroptosis contributes to nephron loss in acute kidney injury (AKI). However, the propagation signals and the underlying mechanisms of the synchronized ferroptosis for renal tubular injury remain unresolved. Here we report that platelet-activating factor (PAF) and PAF-like phospholipids (...
The emergence of PAF and PAF-LPLs in ferroptosis caused the instability of biomembranes and signaled the cell death of neighboring cells. This cascade could be suppressed by PAF-acetylhydrolase (II) (PAFAH2) or by addition of antibodies against PAF. Genetic knockout or pharmacological inhibition ...
蛋白别名:PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; platelet-activating factor acetylhydrolase 2, 40kDa; Platelet-activating factor acetylhydrolase 2, cytoplasmic; Platelet-activating factor acetyltransferase PAFAH2; SD-PLA2; Serine-dependent phospholipase A2 ...
PAF血小板活化因子elisa试剂盒科研专用价格:￥1910/盒产品详情:试剂盒组成及试剂配制 : 1.酶联板(Assay plate ):一块(96孔)。 2. 标准品(Standard):2瓶(冻干品)。 3. 样品稀... 纯度:详见说明书% 包装规格:48T/96T 用途:公司产品仅用于科研
The family of platelet-activating factor-acetylhydrolase (PAF-AH) consists of enzymes which catalyze the hydrolysis of acetyl ester at the sn-2 position of PAF(Platelet-activating factor). The intracellular type II PAF-AH is a single polypeptide about a 40 kd distributed in both the cytosol an...
蛋白别名:PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; platelet-activating factor acetylhydrolase 2, 40kDa; Platelet-activating factor acetylhydrolase 2, cytoplasmic; Platelet-activating factor acetyltransferase PAFAH2; SD-PLA2; Serine-dependent phospholipase A2 ...