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b) a divalent alkanediyl group of 1 to 4 carbon atoms optionally substituted; c) a divalent group or alc猫nediyl alcynediyl of 2 to 4 carbon atoms, optionally substituted; d) a group - (CH2) qU (CH2) r- optionally substituted by -CN; R1, R2, R3, R4, R5, R6, R7, R8 and R9...
-CH2-, or -C(O)NRb; Rb is C1-C3 acyl group; U is -(CH2)e-; e is 1-10 interger; V is II, III, IV; R6 is H, halogen, C1-C6 alkyl group; R7 is C1-C6 alkyl group; X is halide anion such as Cl, Br, I, or mecylate(CH3SO2) and their pharmaceutical salt were prepared...
The present invention describes novel cyclic diol derivatives represented by formulae (I) and (II), in which Y represents O, S, SO, SO2, (CH2)m wherein m is 0 or an integer of 1 to 5, or NRa group wherein Ra is hydrogen, lower alkyl, lower alkoxycarbonyl, aryl, arylalkyl or ...
The compounds (I) are useful due to their antagonist activity of the platelet activating factor. II I III IV V CH3-CO-CH2-COOR' VI R-CHO VII CH3-CO-CH2-COO-(CH2)2-S-R2 VIIILuis SantosPilar OrtegaJaime PriegoMariano Sanchez-CrespoCarlos SunkelDe Casa-Juana Miguel Fau...