You also might need a pacemaker if you have AFib andcongestive heart failure. That’s when your heart can’t pump enoughbloodto the rest of your body the way it should. Atrioventricular (AV) Node Ablation Ifmedicationor other treatments haven’t worked, your doctor might recommend this proced...
Ablation of PDE3A eliminated >85% of the PDE3 activity and increased contractility in hearts from mice lacking PDE3A, but not PDE3B. The enhanced cardiac contractility in (PDE3A KO) hearts was associated with phosphorylation of key proteins involved in the regulation of SR Ca2+ cycling in ...