Activation of the heart normally begins in the sinoatrial node (SAN). Electrical impulses spontaneously released by SAN pacemaker cells (SANPCs) trigger the contraction of the heart. However, the cellular nature of SANPCs remains controversial. Here, we report that SANPCs exhibit glutamatergic ...
These problems could be overcome by means of "biological cardiac pacemakers" obtained from pluripotent stem cells (PSCs). It has been shown that the controlled differentiation of stem cells with TBX, inductors of sinoatrial node cells, and an additional Myh6 promoter-specific antibiotic selection ...
Sinoatrial node cells (SANCs) were isolated from adult guinea pig hearts and were cultured at relatively low cell densities. Within a week, a number of fibroblast-like cells were observed to gather around SANCs, and these formed spontaneously beating clusters with cardiomyocyte structures. The ...
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The sinoatrial node (SAN) is the origin of the electrical signals for rhythmic heartbeats in mammals. The spontaneous firing of SAN pacemaker cells (SANPCs) triggers cardiac contraction. ‘Local Ca2+ release’ (LCR), a unique cellular activity, acts as t
Pacemakercells ofsinoatrial node(SA) have a distinct AP that is characterized bydiastolic depolarizationin phase 4 and relatively slow depolarization in phase 0 that is driven byICa,L(Fig. 1D) rather thanINaas in ventricular myocytes. Diastolic depolarization is driven by inward “funny” currentIf...
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2. In cardiology, a specialized cell or group of cells that automatically generates impulses that spread to other regions of the heart. The normal cardiac pacemaker is the sinoatrial node, a group of cells in the right atrium near the entrance of the superior vena cava. SYN: SEE: pacer3...
2) pacemaker (sinoatrial node) 节律器(窦房结)3) sinus-node self-activity 窦房结自律性4) REM sleep-related sinus arrest 伴随快速动眼睡眠的窦房结节律停止5) sinus [英]['saɪnəs] [美]['saɪnəs] n.窦;窦房结6) sinus rhythm 窦节律...
1. Histamine in allergy and inflammation, mast cells and basophils Mast cell inhibition and reduced ventricular arrhythmias in a swine model of acute myoca... Resident cardiac mast cells, located mainly around coronary vessels and in the right atrium close to the sinoatrial node, are the main ...