Nebulized recombinant tissue plasminogen activator (rt-PA) has the potential to facilitate localized thrombolysis in the alveolar compartment and improve oxygenation. In this proof-of-concept safety study, adults with COVID-19-induced respiratory failure and a 2/FiO2 (P/F) ratio requiring invasive ...
lung injury and PaO2/FiO2 <200 mmHg; 6) serum creatinine >176.8 μmol/L (2.0 mg/dl); 7) bilirubin >34.2 μmol/L (2.0 mg/dl); (8) platelets <100,000/μL; and/or 9) blood coagulation disorders (international normalized ratio (INR) >1.5)...
Based on a different selection of clinical and respiratory (ROX index and PaO2/FiO2 ratio) variables, we devised an AI-driven tool to predict safe discharge from ED, disease severity and mortality during hospitalization. To predict safe discharge our best classifier is an RF integra...
Adjusted regression analysis from symptom day 15 onwards showed a 100mmHg decrease in PaO2/FiO2(primary outcome) for each 37.7pg/ml increase in highest fIL-18 (p<0.03). Per 50pg/ml increase in highest fIL-18, adjusted logistic regression gave an odds-ratio (OR) for crude 60-day mortality...