RSK可以被活化的ERK1/2和3-磷酸肌醇依赖性蛋白激酶1(3-phosphoinositide dependent kinase 1,PDK1)直接磷酸化并激活,并且不受哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路的干扰,如图1所示。
CHK1glucose deprivationP90 RSKphosphorylationβ-TrCPIn solid tumors, cancer cells have devised multiple approaches to survival and proliferate in response to glucose starvation that is often observed in solid tumor microenvironments. However, the precise mechanisms are far less known. Herein, we report...
EGFR mutations increase the expression of TGF‑β via EGFR‑ERK1/2‑p90RSK signaling To investigate the causal relationship between EGFR mutations and TGF-β expression, we constructed mouse LLC and SJT1601 lung cancer cell lines overexpressing human EGFRΔ19, EGFR20ins, or WT...
Park YS, Cho NJ: EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. Mol Cell Biochem. 2012, 370: 191-198. 10.1007/s11010-012-1410-z. Article CAS PubMed Google Scholar ...
The p90 ribosomal S6 kinase (RSK) family comprises four mammalian Ser/Thr kinases (RSK1-4) (Romeo et al.2012). The first RSK family member was identified as a kinase activity in maturatingXenopus laevisoocytes that phosphorylated the 40S ribosomal subunit protein S6 (rpS6) (Erikson and Malle...
Despite being successful in controlling the disease in the majority of men, the high frequency of disease progression to aggressive and therapy resistant stages (termed castrate resistant prostate cancer) has led to the search for new therapeutic targets. The p90 ribosomal S6 kinase (RSK1-4) ...
Therefore we hypothesised that inhibiting the ribosomal S6 kinase p90RSK which is immediately downstream of the MAPK pathway, may be of therapeutic value for the treatment of CLL. Since p90RSK regulates the majority of the anti-apoptotic signaling of the ERK pathway, we investigated the effect of...
RSK activity and/or expression caused a G1 cell cycle block in several tumor lines,14,15 whereas RSK2 overexpression enhanced colony formation even in the absence of tumor promoters.16 Accordingly, elevated RSK1/2 levels were found in several tissue samples from breast and prostate cancer ...
p90 Ribosomal S6 Kinase 2 (p90RSK2) is a substrate of ERK and plays an active role in anti-apoptosis signaling and cell cycle regulation. Our proteomics studies revealed that p90RSK2 is not only activated but also tyrosine-phosphorylated in hematopoietic cells expressing constitutively activated leu...
1 avidity are still not fully understood. Here, we show that activation of the actin-bundling proteinl-plastin (LPL) through phosphorylation at serine-5 enables the formation of clusters containing LFA-1 in high-affinity conformation. Phosphorylation of LPL is induced by an nPKC–MEK–p90RSK...