The p70 S6 kinase is activated by diverse stimuli through a multisite phosphorylation directed at three separate domains as follows: a cluster of (Ser/Thr) Pro sites in an autoinhibitory segment in the noncatalytic carboxyl-terminal tail; Thr-252 in the activation loop of the catalytic domain;...
Both isoforms lie on a mitogen activated signaling pathway downstream of phosphoinositide-3 kinase (PI-3K) and the target of rapamycin, FRAP/mTOR, a pathway distinct from the Ras/MAP kinase cascade (1). The activity of p70 S6 kinase is controlled by multiple phosphorylation events located ...
phosphorylation of p70S6 kinase and to increase its activity in human astroglial cells, and this effect was dependent upon activation of PKC ζ (Guizzetti and Costa, submitted for publication). Ethanol caused a concentration-dependent inhibition of carbachol-induced p70S6 kinase activation, being ...
AF0258p70 S6 Kinase β Rabbit Polyclonal Antibody50μl AZ050Western一抗稀释液50ml —说明书1份 保存条件: p70 S6 Kinase β Rabbit Polyclonal Antibody -20℃保存,Western一抗稀释液-20℃或4℃保存,一年有效。Western一抗稀释液优先推荐4℃保存,长期不使用可以考虑-20℃保存,但冻融可能会导致出现轻微的浑浊...
kinase cascade (1). The activity of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (1). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (1). ...
AF0258p70 S6 Kinase β Rabbit Polyclonal Antibody50μl AZ050Western一抗稀释液50ml —说明书1份 保存条件: p70 S6 Kinase β Rabbit Polyclonal Antibody -20℃保存,Western一抗稀释液-20℃或4℃保存,一年有效。Western一抗稀释液优先推荐4℃保存,长期不使用可以考虑-20℃保存,但冻融可能会导致出现轻微的浑浊...
SpecificityThe antibody detects endogenous level of p70 S6 Kinase only when phosphorylated at serine 424. Immunogen TypePeptide-KLH Immunogen DescriptionPeptide sequence around phosphorylation site of serine 424 (P-V-S(p)-P-V) derived from Human p70 S6 Kinase. Target Namep70 S6 Kinase Modification...
Jose, M.L. Cutler, EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation. BMC Cell Biol. 7 , 34 (2006)Galbaugh T, Cerrito MG, Jose CC, Cutler ML (2006) EGF-induced activation of Akt results in mTOR-...
TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1 Ju Hyun Shin1,3, Sang-Hyun Min1,5, Seong-Jin Kim3, Young-Il Kim1, Junsoo Park4, Heung Kyu Lee2* & Ook Joon Yoo2* 1Department of Biological Sciences, KAIST, 373-1 Guseong-dong, Yuseong-gu,...
中文名称:Anti-Phospho-p70 S6 Kinase Beta 2 (Tyr389) antibody-磷酸化核糖体S6蛋白激酶β2抗体英文名称:Phospho-p70 S6 Kinase Beta 2 (Tyr389) 品牌:沪震生物产地:中国/上海 保存条件:-20°C纯度规格:> 99% 产品类别:抗体 一抗 抗体名:RPS6KB2(phospho Y389); S6K (phospho Y389); p-S6K(Tyr3...