M.SQSTM1介导的NCOA4-LC3相互作用在体内得到了证实,当SQSTM1K420R突变体共转染时,这种相互作用显著减少,揭示K420的泛素化对NCOA4和LC3在体内的相互作用至关重要。N.NCOA4和SQSTM1之间的相互作用在Erastin处理下显著增强,这可以通过...
Impaired autophagy promotes Inflammatory Bowel Disease (IBD). Claudin-2 is upregulated in IBD however its role in the pathobiology remains uncertain due to its complex regulation, including by autophagy. Irrespective, claudin-2 expression protects mice f