Grasso L, Mercer W (1997) Pathways of p53-dependent apoptosis. Vitamins Hormones 53: 139±173Grasso L, Mercer WE (1997) Pathways of p53-dependent apoptosis. Vitam Horm 53:139–173Grasso L, Mercer WE. Pathways of p53-dependent apoptosis [re- view]. Vitam Horm 1997;53:139 -73....
Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells. FASEB J 2002;16:1423-1425.Mayr M, Hu Y, Hainaut H, Xu Q. Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis ...
In addition, they show that the p53 transcription-dependent and transcription-independent pathways of apoptosis are genetically separable and synergistically cooperate in inducting apoptosis. Further understanding of the mechanism of p53-dependent apoptosis will be vital to its application in cancer therapy....
Thymocyte apoptosis can therefore occur through at least two distinct pathways: (1) a DNA damage-induced response, which requires an intact p53 pathway; and (2) a glucocorticoid-mediated process that is independent of p53 status. Since Puma expression is induced by p53 as well as glucocorticoids...
One must appreciate the complexity of p53-induced apoptosis, and understand that all p53-regulated cell death pathways are not equal. This notion is highlighted by the trans-activation-deficient double mutant L25Q, W26STrp53knock-in (referred to asp53QS).24,25Mouse embryonic fibroblasts derived ...
translocation and transcriptional activity. This study presents the first evidence that FGF1 and p53 pathways interact in neuronal cells, and that FGF1 protects neuronal cells from p53-dependent apoptosis, suggesting that alterations of FGF1/p53 crosstalk could be involved in a large range of ...
In summary, Egr-1 suppressed transformation and counteracted apoptosis by the coordinated activation of TGF尾1, FN, p21 and FAK, leading to enhanced cell attachment and reduced caspase activity. In the doubly expressing cell line, the survival effect of Egr-1 was dominant over the apoptotic ...
In support of this notion, previous work suggested that apoptosis following treatment with p53-reactivating drugs requires activation of the ISR95,96. In sum, our results illuminate a mechanism by which the PPM1D phosphatase coordinately opposes two major stress signaling pathways, the p53 network ...
Signaling targets of Jak kinase pathways included members of the Bcl-2 family of anti-apoptotic proteins, and enforced expression of Bcl-2 or Bcl-xwas as effective as cytokine treatment in blocking IR-induced apoptosis but did not prevent growth arrest. A distinct signal derived from a membrane...
The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1-T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways J Immunol, 160 (1998), pp. 5735-5741 CrossrefView in ScopusGoogle Scholar Kobayashi et al., 1998 T. Koba...