[4] Ceskova P, Chichger H, Wallace M, Vojtesek B, Hupp TR.On the Mechanism of Sequence-specific DNA-dependent Acetylation of p53: The Acetylation Motif is Exposed upon DNA Binding.J Mol Biol. 2006 Mar 24;357(2):442-56. [5] Jiang PH, Motoo Y, Garcia S, Iovanna JL, Pebusque ...
大家好,今天分享一篇发表在JACS上的文章,题目为“Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53”,文章通讯作者为西奈山伊坎医学院的金坚教授,他们课题组主要研究方向是发现组蛋白甲基转移酶的选择性抑...
蛋白层面的调节 p53蛋白可经历多种类型的PTM,包括ubiquitination、phosphorylation、acetylation、methylation、SUMOylation、NEDDylation、OGlcNAcylation、ADP-ribosylation、UFMylation、hydroxylation、β-hydroxybutyrylation、sulfation及isoLG adduction。不同的刺...
ACETYLATIONACYLATIONP53 proteinDNA-binding proteinsPHOSPHOPROTEINSTUMOR suppressor proteinsDiscusses research on the use of acetylation to control the activity of p53 protein. Reference to a study by Wei Gu and colleagues published in the November 16, 2000 issue of "Nature"journal; Impact of ...
p53在细胞遇到不同的刺激时表现出不同的功能, 而p53之所以能够呈现功能的多样化, 是因为p53受到多种类型翻译后修饰的精细调节. p53蛋白的翻译后修饰是调控p53应对多种不同信号刺激做出不同应答的重要机制. P53蛋白的翻译后修饰包括磷酸化(phosphorylation)、泛素化(ubiquitination)、乙酰化(acetylation)、甲基化(meth- ...
Wang SJ, Li D, Ou Y, Jiang L, Chen Y, ZhaoY, Gu W. 2016. Acetylation Is crucial for p53-mediated ferroptosis and tumor suppression[J].Cell Rep. 2016. 云南洛宇生物科技有限公司(简称洛宇生物)是云南省第一家有自主研发创新科研平台的第三方企业,公司技术架构完整,服务流程明确,研发水平过硬,已...
因此，通过探索新的缓解心脏重塑的分子及其机制是目前亟待研究的。生长抑制因子2（Ing2）前期作为肿瘤抑制基因被广泛研究，但近 Inhibitor of growth protein-2silencing alleviates angiotensin II-induced cardiac remodeling in mice by reducing p53acetylation LIU Zhengwang 1,QIU Xiaotang 2,YANG Hua 1,WU Xiaocui...
(2006). Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol 26: 6859–6869. Article CAS PubMed PubMed Central Google Scholar Chen X, Ko LJ, Jayaraman L, Prives C . (1996). p53 levels, functional domains, and DNA damage ...
(PubMed:21317932). It is unclear whether AMP directly mediates phosphorylation at Ser-15. Phosphorylated on Thr-18 by isoform 1 and isoform 2 of VRK2. Phosphorylation on Thr-18 by isoform 2 of VRK2 results in a reduction in ubiquitination by MDM2 and an increase in acetylation by EP300....
p53蛋白可经历多种类型的PTM,包括ubiquitination、phosphorylation、acetylation、methylation、SUMOylation、NEDDylation、OGlcNAcylation、ADP-ribosylation、UFMylation、hydroxylation、β-hydroxybutyrylation、sulfation及isoLG adduction(参见p53翻译后修...