Aberrant patternKi-67PredictorThe aim of this study was to analyze the role of Ki-67, p53, and the "aberrant p53 pattern" in squamous cell carcinomas of the nasal vestibule. Patients between 1995 and 2014 were included. Baseline characteristics and outcome were analyzed with respect to ...
In our study, we evaluated whether a more comprehensive evaluation of p53 staining patterns can predict the mutational status of TP53 in BC, including the consideration of the CY pattern as an additional form of aberrant expression. We aimed to correlate these patterns with specific types of ...
p62, Parkin and Beclin-1. In the absence of p53 under basal conditions, the autophagy proteins p62, Parkin and Beclin-1 were upregulated by 2.4–3-fold (Fig.5A,C–E). LC3-I and LC3-II levels were unaffected (Fig.5A,B). It should be noted that this pattern differs somewhat ...
Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 1991;6:1699–1703. 19 Chang K, Ding I, Kern FG, et al. Immunohistochemical analysis of p53 and her-2/neu proteins in human tumors. J Histochem Cytochem 1991;39:1281–1287. ...
Mutp53 has the capacity to cause a genomic abnormality by stopping the replication of DNA. Similar to how some mutp53 proteins trigger Cyclin A to encourage the growth of the intra-S phase checkpoint and the DNA replication origin kinase CHK1 to help duplicate aberrant genomic DNAs by stabil...
In other cell lines, complete loss and an aberrant migration pattern of Rb protein expression were observed. Comparative genomic hybridization suggested that the homozygous deletions of the p15, p16 and p14 were subtle chromosomal deletions and could not be identified by standard karyotyping in some ...
We have also shown that interaction of p53 with single-stranded (ss)DNAs results in a different pattern of selective proteolysis. This interaction gives a novel of 50-kDa protein generated by C-terminal cleavage of the full length protein and released from the p53-ssDNA complexes. Here we ...
Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype Leukemia, 22 (2008), pp. 1539-1541 10.1038/leu.2008.143 CrossrefView in ScopusGoogle Scholar 10 J Bartek, R Iggo, J Gannon Genetic and immunochemical analysis of mutant p53 in human...
Aberrant p53 can be seen in the nuclei. b Staining pattern of tumors with mortalin expression (magnification, ×400). Mortalin can be seen in the cytoplasm. Staining pattern of aberrant p53 (c) and mortalin (d) in consecutive sections of the same sample. Mortalin-positive tumor cells ...
25 Moreover, large number of aberrant Hox gene expression have been found in various cancers.26 Next, we asked whether any of Hox genes were influenced by TUG1, thus participating in tumor progression. qRT-PCR analysis was performed to detect the expression of HOX genes. The results showed ...