We report a case of an adamantinoma demonstrating heretofore unreported immunohistochemical expression of p40 that was interpreted to be a metastatic squamous cell carcinoma on the biopsy. This misdiagnosis can be attributed to anchoring bias from the submitted clinical information and this...
Adenocarcinoma (N = 142) Squamous cell carcinoma (N = 104) N (%) N (%) Napsin A+ / p40- 123 (87%) 0 (0%) Napsin A+ / p40+ 10 (7%) 0 (0%) Napsin A- / p40+ 0 (0%) 102 (98%) Napsin A- / p40- 9 (6%) 2 (2%)...
The tumor cells diffusely co-expressed p40 and TTF1, exhibiting a dual immunophenotype characteristic of both squamous cell carcinoma and adenocarcinoma. Molecular testing of four NSCLC co-expressing p40 and TTF1 revealed the presence of common EGFR mutations, as well as mutations of NRAS (mutation...
Gynecol Oncol 83(2): 235–243 Hazelbag S, Kenter G, Gorter A, Dreef E, Koopman L, Violette S, Weinreb P, Fleuren G (2007) Overexpression of the alphavbeta6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. J Pathol 212(3): 316–324 Hazelbag...
adenocareinomaofnon一.smallcelllungcancer.Methods:Theexpressionofp63,p40,CK5/6,TI’F一1,CK7andNapsin—A wasdetectedin51caseswithnon--smallcelllungcancerbyusingimmunohistochemistryofSP.Results:In51casesw i th non一. smallce1. 【lungcancer.therewere20caseswithsquamouscellcarcinomaand31caseswithadenocarci...
the negative rate was 12.05%.There was nosignificant difference in the expressions of p63 and p40 in different age and location of cervical squamous cell carcinoma(χ 2 =1.17,1.75,0.52,0.71, P > 0.05),but there were significant differences in the expressions of p63 and p40 in differenttumor...
【摘要】Objective:To study the significant immunohistochemical mark to identifiy squamous cell carcinoma and adenocarcinoma of non-small cell lung cancer. Methods:The expression of p63, p40, CK5/6, TTF-1, CK7 and Napsin-A was detected in 51 cases with non-small cell lung cancer by using immu...
Positive IHC detected in human lung squamous cell carcinoma tissueNote: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 Positive IF/ICC detected in HeLa cells Recommended dilution ApplicationDilution Western Blot (WB)...
p40 is the short form of the p53 homologue gene p63, also named ∆Np63, and its antibody has recently been introduced as a highly specific diagnostic marker of the squamous cell carcinoma of the lung. Nevertheless its expression has been found in many other unconventional sites (e.g. ...
The p40 gene maps to human chromosomal arm 3q, a region known for aberrations including deletions and amplifications in human cancers, such as bladder cancer. Amplifications of this region of chromosomal arm 3q have been observed in squamous cell carcinomas. Such carcinomas occur in head, neck...