Bladder urothelial carcinoma showed immunoreactivity for GATA-3 in 99% (88/89), p40 in 87% (77/89) and uroplakin II in 80% (71/89) of cases, with a positive correlation between GATA-3 and uroplakin II H-score (0.44;p<聽0.0001). All lesions were positive for at least one marker, ...
p40 is the short form of the p53 homologue gene p63, also named ∆Np63, and its antibody has recently been introduced as a highly specific diagnostic marker of the squamous cell carcinoma of the lung. Nevertheless its expression has been found in many other unconventional sites (e.g. ...
Atezolizumab monotherapy versus chemotherapy in untreated locally advanced or metastatic urothelial carcinoma (IMvigor130): final overall survival analysis from a randomised, controlled, phase 3 study Background The primary analysis of IMvigor130 showed a significant progression-free survival benefit with ...
ISUP classification revealed 19.2% PNULMP, 23.6% LGPC, 39.4% HGPC, 9.6% non-papillary urothelial carcinomas (NPUC), and 7.9% as carcinoma in situ (CIS). Tumour staging depicted an overall 11.5% of tumours with stage Ta and 31.5% with stage T3-4. Among 71% invasive carcinomas, 16% ...
Efficacy and Tolerability of Enfortumab Vedotin for Metastatic Urothelial Carcinoma: Early Experience in the Real World Additionally, EV was the first approved drug as ADC for malignancies of the genitourinary system (7).The current study aimed to assess the early ... A Minato,R Kimuro,D Ohno...