摘要 目的:基于TLR4/p38MAPK/AP-1信号通路探讨心痛泰对兔动脉粥样硬化和血管重构的影响。方法:日本大耳白兔120只随机分为空白组,模型组,心痛泰低、中、高剂量组和瑞舒伐他汀组。采用前瞻性实验研究,造模的同时给予药...展开更多 Objective:To study on the effects of Xintongtai(XXT)reducing atherosclerosis and...
p38 MARK是炎症反应和免疫反应中的关键调控因子。在炎症反应中,p38 MARK通过激活NF-κB、AP-1等转录因子,促进炎症介质的表达和释放;同时,p38 MARK还参与调控炎症细胞的迁移和浸润。在免疫反应中,p38 MARK则通过调控免疫细胞的增殖、分化和功能,参与免疫应答的调控。 三、p38 MARK在癌症研究中的进展 1.癌症发生与发...
daphnegiravone D (1), and four known (2–5) prenylated flavonoids were isolated fromDaphne giraldii. Their cytotoxic activities revealed that daphnegiravone D markedly inhibited the proliferation of cancer cells, but had no apparent cytotoxicity on human normal cells. Mechanistically...
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此前研究表明,线粒体 CaMKII 通过 MAPK/AP-1 信号通路参与线粒体氧化应激和心房重构。但 MsrA 在 ROS 诱导的 AF 中对 ox-CaMKII 和 MAPK 信号通路的介导作用尚未完全阐明,且缺乏药物治疗策略。 基于此,北部战区总医院心外科王辉山教授团队发表了题目为:"S-methyl-L-cysteine targeting MsrA attenuates Ang II-...
The phosphorylated ERK2-MEK1 chimera activates c-Fos transcription factor and the activating protein (AP)-1 heterodimer which regulates the IFN-γ gene promoter and subsequent cytokine production [66, 67]. Increased phosphorylation of MEK1/2 may therefore result in increased production of IFN-γ ...
eNOS）等。Cav-1可与其余信号链分子相互作用并调节其活性。Wang的研究证实[11]：Cav-1可增加P38的磷酸化并降低MAPKs及PI3K的活化。在化学上抑制P38的活化消除了Cav-1对LPS诱发的炎症产物，如TNF-α, IL-6,及IL-10的调节。用LPS处理细胞，可导致NF-κB及AP-1结合活动增强。而Cav-1的高 ...
1.一种如式I所示的化合物、其消旋体、立体异构体、互变异构体、同位素标记物、溶剂化物、药学上可接受的盐或其前药:其中,W为CH或N;m为0‑5的整数;n为0‑3的整数;环A为3‑20元的含氮杂环基,除与母核 连接的N原子以外,还任选地含有1个、2个或更多个选自O、N或S的杂原子;R选自H、卤素、CN和C...
p38 isoforms have opposite effects on AP-1-dependent transcription through regu- lation of c-Jun - The determinant role of the isoforms in the p38 MAPK signal specific- ity. Journal of Biological Chemistry 278:4831-4839.PRAMANIK R, QI X, BOROWICZ S, et al. p38 isoforms have opposite ...
Both the p38 and JNK MAPK pathways and the downstream transcription factor c-Jun/AP-1 are required for the VDR stimulation, as revealed by application of their dominant negatives, the specific p38 inhibitor SB203580, and site-directed mutagenesis of the AP-1 element in the VDR promoter. The ...