合成酸化细胞质调控机制磷酶生物学文章简介近年来的研究表明,p300可以乙酰化细胞质中的蛋白,参与调控细胞质中的生物学过程;p300通过乙酰化自噬相关蛋白LC3,Atg5和Atg7等,在细胞内重要的分解代谢过程自噬的起始中发挥关键作用.然而,人们对细胞内p300的活性调控机制却知之甚少.Wei Wan...
㊀㊀［摘要］㊀自噬是一个 自我吞噬 的过程，是对细胞内无用的物质进行代谢再利用的途径㊂乙酰转移酶ｐ３００是一种多功能的转录辅激活因子，在转录调控及蛋白修饰过程中起着重要的作用㊂ｐ３００作为自噬上游的有效阻滞剂，主要是通过激活ｍＴＯＲＣ１来抑制自噬，同时也可以乙酰化Ａｔｇ５㊁Ａｔｇ７㊁...
The Human FSGS⁃Causing ANLN R431C Mutation Induces Dysregulated PI3K / AKT / mTOR / Rac1 Signaling in Podocytes. J Am Soc Nephrol, 2018,29(8) :2110⁃2122. 8 陈姗, 刘志红, 郑敬民, 等. 脂蛋白肾病患者载脂蛋白 E 基因全 长序列分析.肾脏病与透析肾移植杂志,2005,14(3) :218⁃223. ...
et al. PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer. Sci Rep. 2017:7 21. Smith AM, Zhang CRC, Cristino AS, Grady JP, Fink JL, Moore AS. PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors. Oncotarget...
DCN通过抑制Akt/mTOR/p70S6K通路促进促自噬AMPK信号级联并抑制抗自噬信号,然后在内皮细胞中诱导自噬。线粒体是产生能量的重要细胞器,通过氧化磷酸化将各种能量底物转化为ATP。氧化磷酸化和自噬之间存在着密切的联系,自噬与能量产生的改变有关。根据上述已发表的报道,我们继续进行细胞实验,分析DCN可能负责OGD诱导损伤的...
In addition to the classic MAPK pathway, overexpressed IQGAP1 has also been shown to act as a scaffold protein in the PI3K/Akt signaling cascade to promote the interaction of mTOR and Akt. Show abstract LncRNA MALAT1 was regulated by HPV16 E7 independently of pRB in cervical cancer cells ...
Disease-associated astrocyte epigenetic memory promotes CNS pathology Hong-Gyun Lee Joseph M. Rone Francisco J. Quintana Nature (2024) Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation Terytty Yang Li Qi Wang Johan Auwerx Cell Discovery (2023)Associated...
Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1 PLoS Biol., 13 (2015), p. e1002243 Google Scholar Wang et al., 2017 Y. Wang, Y.R. Guo, K. Liu, Z. Yin, R. Liu, Y. Xia, L. Tan, P. Yang, J.H. Lee, X.J. Li, et al. KAT2A coupled...
inhibitors in patients diagnosed with TNBC. In the in vitro and in vivo MDA-MB-231 murine xenograft models, the above-mentioned birabresib showed antiproliferative activity, repressed the c-MYC protein, and synergized with the mTOR inhibitor everolimus [19]. We observed a similar effect of I-...
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